Trim67 Gene Summary [Mouse]
Predicted to enable zinc ion binding activity. Acts upstream of or within negative regulation of Ras protein signal transduction; positive regulation of neuron projection development; and positive regulation of ubiquitin-dependent protein catabolic process. Located in cytoplasm. Is expressed in brain; dorsal root ganglion; and spinal cord. Orthologous to human TRIM67 (tripartite motif containing 67). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trim67 |
| Official Name | tripartite motif-containing 67 [Source:MGI Symbol;Acc:MGI:3045323] |
| Ensembl ID | ENSMUSG00000036913 |
| Bio databases IDs | |
| Aliases | tripartite motif-containing 67 |
| Synonyms | D130049O21Rik, RGD1560667, TNL, tripartite motif-containing 67 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trim67 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- B-box-type zinc finger superfamily
- B-Box C-terminal domain
- SPRY domain
- FN3
- zinc finger of C3HC4-type, RING
- B-box zinc finger
- protein binding
- Fibronectin type 3 domain
- SPRY-associated domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trim67 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- negative regulation of Ras protein signal transduction
- regulation of protein localization
- positive regulation of neuron projection development
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding