Vdac2 Gene Summary [Mouse]
Enables oxysterol binding activity and voltage-gated monoatomic ion channel activity. Involved in negative regulation of intrinsic apoptotic signaling pathway and negative regulation of protein polymerization. Located in mitochondrion and sperm midpiece. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human VDAC2 (voltage dependent anion channel 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vdac2 |
| Official Name | voltage-dependent anion channel 2 [Source:MGI Symbol;Acc:MGI:106915] |
| Ensembl ID | ENSMUSG00000021771 |
| Bio databases IDs | |
| Aliases | voltage-dependent anion channel 2 |
| Synonyms | mVDAC2, mVDAC6, POR, Vdac6, voltage-dependent anion channel 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vdac2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- oxysterol binding
- cholesterol binding
- sphingolipid binding
- Eukaryotic porin
- binding protein
- phospholipid scramblase
- Eukaryotic porin family that forms channels in the mitochondrial outer membrane
- voltage-dependent ion-selective channel
- protein binding
- voltage-gated ion channel
- ion channel
Pathways
Biological processes and signaling networks where the Vdac2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lymphomagenesis
- colorectal cancer
- breast cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- idiopathic dilated cardiomyopathy
- osteosarcoma
- osteosarcomagenesis
- lymphoma
- atopic dermatitis
role in cell
- cell death
- apoptosis
- activation in
- synthesis in
- binding
- josamycin sensitivity
- dysfunction
- permeabilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cellular membrane
- Plasma Membrane
- Mitochondria
- mitochondrial membrane
- mitochondria-associated membranes
- mitochondrial nucleoids
- mitochondrial outer membrane
- sperm midpiece
- acrosome
- synaptic vesicles
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vdac2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- binding of sperm to zona pellucida
- negative regulation of protein polymerization
- anion transport
- negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial membrane
- sperm midpiece
- acrosomal vesicle
- mitochondrion
- membrane
- pore complex
- mitochondrial outer membrane
- mitochondrial nucleoid
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- ceramide binding
- voltage-gated anion channel activity
- porin activity
- protein binding
- cholesterol binding
- oxysterol binding
- phosphatidylcholine binding