Plekha2 Gene Summary [Mouse]
Enables PDZ domain binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in positive regulation of cell-matrix adhesion. Predicted to be located in membrane. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including bone; central nervous system; jaw; thymus primordium; and vomeronasal organ. Orthologous to human PLEKHA2 (pleckstrin homology domain containing A2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plekha2 |
| Official Name | pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2 [Source:MGI Symbol;Acc:MGI:1928144] |
| Ensembl ID | ENSMUSG00000031557 |
| Bio databases IDs | |
| Aliases | pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2 |
| Synonyms | 6430512N22Rik, pleckstrin homology domain containing A2, pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2, TAPP2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plekha2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- laminin binding
- PH domain
- protein binding
- Pleckstrin homology-like domain
- fibronectin binding
- PDZ-domain binding
Pathways
Biological processes and signaling networks where the Plekha2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glomerulonephritis
- COVID-19
- neuroticism
role in cell
- expression in
- proliferation
- phosphorylation in
- adhesion
- frequency
- respiration
- spare respiratory capacity
- glycolysis in
- development
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plekha2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell-matrix adhesion
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- fibronectin binding
- PDZ domain binding
- lipid binding
- phosphatidylinositol-3,4-bisphosphate binding
- laminin binding