Cd2 Gene Summary [Mouse]
Enables identical protein binding activity. Predicted to be involved in several processes, including natural killer cell activation; natural killer cell mediated cytotoxicity; and positive regulation of cytokine production. Located in several cellular components, including cell-cell junction; cytoplasmic side of plasma membrane; and external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human CD2 (CD2 molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd2 |
| Official Name | CD2 antigen [Source:MGI Symbol;Acc:MGI:88320] |
| Ensembl ID | ENSMUSG00000027863 |
| Bio databases IDs | |
| Aliases | CD2 antigen |
| Synonyms | CD2 antigen, CD2 molecule, CD2R, Erythrocyte receptor, LFA-2, LFA3R, LFA-3 receptor, LOC100128308, Ly-37, OX-34, SRBC, T11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- protein kinase binding
- immunoglobulin domain
- PPPGHR motif
- ectodomain
- protein binding
- receptor binding
- proline rich domain
- identical protein binding
- cytoplasmic domain
- receptor tyrosine kinase binding
- ligand-binding domain
- transmembrane domain
- cell adhesion recognition domain
- immunoglobulin-like protein domain
- intracellular domain
- cytosolic tail domain
- transmembrane receptor
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Waldenström macroglobulinemia
- psoriasis
- liver cancer
- plaque psoriasis
- acute myeloid leukemia
- graft-vs-host disease
- systemic mastocytosis
- hypothyroidism
- aggressive NK-cell leukemia
- early precursor T-cell acute lymphoblastic leukemia
role in cell
- production in
- activation
- activation in
- aggregation
- adhesion
- cell death
- proliferation
- cellular infiltration by
- apoptosis
- cytotoxicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- Golgi Apparatus
- intercellular junctions
- cytoplasmic face of plasma membrane
- plasma membrane extracellular face
- nucleoplasm
- membrane blebs
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T cell activation
- cell surface receptor signaling pathway
- natural killer cell mediated cytotoxicity
- regulation of T cell differentiation
- positive regulation of myeloid dendritic cell activation
- positive regulation of interleukin-8 production
- membrane raft polarization
- positive regulation of interferon-gamma production
- apoptotic process
- natural killer cell activation
- positive regulation of tumor necrosis factor production
- heterotypic cell-cell adhesion
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- external side of plasma membrane
- macromolecular complex
- Golgi apparatus
- extracellular region
- plasma membrane
- internal side of plasma membrane
- nucleoplasm
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- signaling receptor activity
- receptor tyrosine kinase binding
- receptor binding