Interleukin 10 (IL-10) is a cytokine with diverse, but mostly anti-inflammatory, effects on hematopoietic cells. It also regulates the growth and differentiation of B-cells, T-cells, NK-cells and dendritic cells.IL-10 binds IL-10Rα, the ligand binding chain of the tetrameric receptor. IL-10Rbeta serves to assemble the active receptor complexes and is shared with other IL-10 related cytokines. The binding of ligand to IL-10Rα induces a conformational change that enables IL-10Rβ to interact with the newly formed ligand-receptor complex...