Target List
Oncogenes
BAX, BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), CASP8 (FLICE), CDK4, ELK1, ETS1, HGF, JAK2, JUNB, JUND, KIT (CD117), KITLG (SCF), KITLG (SCF), MCL1, MET, MOS, MYB, NFKBIA (IκBα, MAD3), NRAS, PIK3CA (p110-alpha), PML, PRKCA, RAF1, RARA, REL, ROS1, RUNX1 (AML1), SRC, STAT3, ZHX2
Tumor Suppressor Genes
ATM, BRCA1, BRCA2, CDH1 (E-Cadherin), CDKN2B (p15INK4b), CDKN3, E2F1, FHIT, FOXD3, HIC1, IGF2R, MEN1, MGMT (AGT), MLH1, NF1, NF2, RASSF1, RUNX3, S100A4, SERPINB5 (Maspin), SMAD4 (MADH4), STK11 (LKB1), TP73, TSC1, VHL, WT1, WWOX, XRCC1
Both Oncogenic & Tumor Suppressor Properties
BCR, EGF, ERBB2 (HER-2, NEU), ESR1 (ERα), FOS, HRAS, JUN, KRAS, MDM2, MYC, MYCN, NFKB1, PIK3C2A, RB1, RET, SH3PXD2A, TGFB1, TNF, TP53 (p53)
Transcription Factors
ABL1, BRCA1, BRCA2, CDKN2A (P16INK4A), CTNNB1, E2F1, ELK1, ESR1 (ERα), ETS1, FOS, FOXD3, HIC1, JUN, JUNB, JUND, MDM2, MEN1, MYB, MYC, MYCN, NF1, NFKB1, PML, RARA, RB1, REL, RUNX1 (AML1), RUNX3, SMAD4 (MADH4), STAT3, TGFB1, TNF, TP53 (p53), TP73, TSC1, VHL, WT1, ZHX2
Epithelial-to-Mesenchymal Transition (EMT)
BRCA2, CDKN2B (p15INK4b), CTNNB1, ERBB2 (HER-2, NEU), HGF, JAK2, KIT (CD117), MCL1, NF1, RUNX3, S100A4, SMAD4 (MADH4), TGFB1, VHL
Angiogenesis
AKT1, CTNNB1, EGF, ERBB2 (HER-2, NEU), NF1, PML, RUNX1 (AML1), TGFB1
Apoptosis
BAX, BCL2, BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), BRCA1, CASP8 (FLICE), E2F1, MCL1, MGMT (AGT), TNF, VHL
Cell Adhesion Molecules
APC, CDH1 (E-Cadherin), CDKN2A (P16INK4A), CTNNB1, KITLG (SCF), KITLG (SCF), NF1, NF2, TGFB1
Cell Cycle
ATM, BRCA1, BRCA2, CCND1, CDK4, CDKN1A (p21CIP1, WAF1), CDKN2A (P16INK4A), CDKN2B (p15INK4b), CDKN3, E2F1, HGF, MEN1, STK11 (LKB1), TP53 (p53)