Chronic myeloid leukemia (CML) is a biphasic disease, triggered by expression of the BCR/ABL fusion gene product in hematopoietic stem cells (HSCs). HSCs can differentiate into common myeloid progenitors (CMPs), which then differentiate into progenitors for the granulocyte/macrophage cell series and lymphocyte series. The initial chronic phase of CML (CML-CP) is characterized by a massive expansion of the granulocytic-cell series. Acquisition of additional genetic mutations in addition to the expression of BCR/ABL causes the progression of CML from chronic phase to blast phase (CML-BP), characterized by an accumulation of myeloid or lymphoid blast cells.The BCR/ABL fusion gene encodes p210BCR/ABL; an oncoprotein has constitutive tyrosine kinase activity and is predominantly localized in the cytoplasm...