Target List
Leukemia
Acute Lymphoblastic Leukemia (ALL)
ABL1, ABL2 (ARG), BIRC3 (c-IAP2), BRAF, BTK, CDKN2A (P16INK4A), CDKN2B (p15INK4b), CREBBP (CBP), CRLF2 (TSLPR), EBF1, EP300, ETV6, FBXW7, FLT3, GATA3, HRAS, IKZF1, IL7R, JAK1, JAK2, JAK3, KDM6A, KMT2A, KRAS, MYC, NOTCH1, NRAS, PAX5, PDGFRB, PLCG2, PTEN, PTPN11, RUNX1 (AML1), SF3B1, SH2B3, TP53 (p53)
Acute Myeloid Leukemia (AML)
ANKRD26, ASXL1, ATRX, BRCA1, BRCA2, CBFB, CBLB, CBLC, CCND2, CDC25C, CEBPA, CUX1, DCK, DDX41, DHX15, DNMT3A, ELANE, ETV6, FLT3, GATA1, GATA2, GNAS, HRAS, IDH1, IDH2, IKZF1, IKZF2, IKZF3, JAK2, KDM6A, KIT (CD117), KMT2A, KRAS, LUC7L2, MTOR, NPM1, NRAS, NUP214, PDGFRA, PICALM, PRPF8, PTPN11, RB1, RBBP6, RPS14, RUNX1 (AML1), SF3B1, SLC29A1, SMC1A, TERT, TET1, TET2, TP53 (p53), U2AF1, U2AF2, WT1, ZEB2
Acute Promyelocytic Leukemia (APML; APL)
CEBPA, NPM1, NUMA1, RARA, RUNX1 (AML1)
Atypical Chronic Myeloid Leukemia (aCML)
ASXL1, CBL, CEBPA, EZH2, FLT3, JAK2, KRAS, NPM1, NRAS, RUNX1 (AML1), SETBP1, SRSF2, TET2, U2AF1
Chronic Lymphocytic Leukemia (CLL)
ATRX, BCL2, BIRC3 (c-IAP2), BRAF, CBLB, CCND2, CD38, CUX1, GNAS, GNB1, LUC7L2, MYD88, NOTCH1, NRAS, PTPN11, SF3B1, TP53 (p53), U2AF2, XPO1, ZAP70
Chronic Myeloid Leukemia (CML)
ABL1, ASXL1, BCOR, BCR, BRAF, CBL, CREBBP (CBP), DNMT3A, DNMT3B, EZH2, IDH1, IDH2, IKZF1, JAK2, KRAS, NPM1, NRAS, RUNX1 (AML1), TET1, TET2, TP53 (p53), WT1
Chronic Myelomonocytic Leukemia (CMML)
ASXL1, BCOR, BCORL1, CBL, CEBPA, DNMT3A, EZH2, FLT3, IDH1, IDH2, JAK2, KIT (CD117), KRAS, MPL, NF1, NPM1, NRAS, PHF6, PTPN11, RUNX1 (AML1), SETBP1, SF3B1, SRSF2, STAG2, TET2, TP53 (p53), U2AF1, ZRSR2
Hairy Cell Leukemia
BRAF, CDKN1B (P27KIP1), MAP2K1, TP53 (p53)
Juvenile Myelomonocytic Leukemia
ARHGAP26, CBL, KRAS, NRAS, PTPN11
Lymphomas
Acute Lymphocytic Lymphomas
BIRC3 (c-IAP2), BTK, CDKN2A (P16INK4A), CDKN2B (p15INK4b), MYC, NOTCH1, PLCG2, SF3B1, TP53 (p53)
B Cell Lymphomas
BCL6, BRAF, CD79A, CHEK2 (RAD53), EZH2, MAP2K1, MYD88, STAT6, TNFRSF14, TP53 (p53)
Burkitt Lymphomas
CBLB, GNA13, H1-4, MTOR, MYC
Diffuse Large B Cell Lymphomas
B2M, BCL2, CBLB, GNA13, H1-4, KMT2D, MTOR, PIM1, PRPF8, SOCS1, TNFAIP3
Follicular Lymphomas
ARID1A, BCL10, BCL2, CARD11, CREBBP (CBP), EP300, EZH2, FOXO1, KMT2D, MEF2B
Mantle Cell Lymphomas
ATM, CCND1
Marginal Zone Lymphomas
KLF2, MYD88, NOTCH2, TNFAIP3, TP53 (p53)
Mucosa-Associated Lymphoid Tissue (MALT) Lymphomas
BCL10, TNFAIP3
Non-Hodgkin Lymphomas
BRAF, CASP10 (MCH4), NRAS, PIK3CA (p110-alpha), RAD54B, RAD54L, TP53 (p53)
Primary Cutaneous Lymphomas
CD79B, MYD88
Small Lymphocytic Lymphomas
ATRX, BCL2, CBLB, CCND2, CUX1, GNAS, LUC7L2, U2AF2, XPO1
T Cell Lymphomas
ARID1B, ATM, CBLB, CCR4, DNMT3A, IDH1, IDH2, INO80, JAK1, JAK3, RHOA, SETD2, STAT3, STAT5B, TET2
Myelodysplastic Syndromes & Myeloproliferative Neoplasms
Myelodysplastic Syndromes
ANKRD26, ASXL1, ATRX, BCOR, BCORL1, CALR, CBL, CEBPA, CSF3R (GM-CSFR), CUX1, DDX41, DKC1, DNMT3A, ETNK1, ETV6, EZH2, FLT3, GATA2, GNAS, GNB1, IDH1, IDH2, JAK2, JAK3, KIT (CD117), KRAS, MPL, NF1, NPM1, NRAS, PHF6, PIGA, PPM1D, PTPN11, RAD21, RUNX1 (AML1), SAMD9, SAMD9L, SETBP1, SF3B1, SMC3, SRP72, SRSF2, STAG2, STAT3, TERC, TERT, TET2, TP53 (p53), U2AF1, WT1, ZRSR2
Myeloproliferative Neoplasms
ASXL1, BCOR, CALR, CBL, CSF3R (GM-CSFR), DNMT3A, ETV6, EZH2, IDH1, IDH2, JAK2, KIT (CD117), MPL, NOTCH1, NRAS, PDGFRA, RUNX1 (AML1), SETBP1, SF3B1, SH2B3, SRSF2, STAT3, STAT5B, TET2, TP53 (p53), U2AF1, ZRSR2
Other Myeloid Neoplasms
Essential Thrombocythemia
ASXL1, CBL, IDH2, JAK2, MPL, SF3B1, TET2, TP53 (p53)
Multiple Myeloma
ATM, BARD1, BRAF, BRCA1, BRCA2, BRIP1, CHEK1, CHEK2 (RAD53), CXCR4, EGFR (ERBB1), ERBB2 (HER-2, NEU), FANCL, FGFR3, IDH1, IDH2, KIT (CD117), KRAS, MET, NRAS, PALB2, PDGFRA, RAD51B, RAD51C, RAD51D, RET, TP53 (p53)
Plasma Cell Myeloma
HRAS, MTOR, RB1, SLC29A1
Polycythemia Vera
ASXL1, DNMT3A, EZH2, IDH1, JAK2, NRAS, TET2, TP53 (p53)
Primary Myelofibrosis
ASXL1, CBL, DNMT3A, EZH2, IDH1, IDH2, JAK2, MPL, NF1, NRAS, SETBP1, SF3B1, SRSF2, TET2, TP53 (p53)
Systemic Mastocytosis
ASXL1, CBL, DNMT3A, ETV6, EZH2, IDH2, JAK2, KIT (CD117), KRAS, NPM1, NRAS, RUNX1 (AML1), SETBP1, SF3B1, SRSF2, TET2, TPSAB1, U2AF1
Waldenstrom Macroglobulinemia
CXCR4, MYD88