Target List
Leukemia
Acute Lymphoblastic Leukemia (ALL)
ABL1, BRAF, BTK, CDKN2A (P16INK4A), CREBBP (CBP), ETV6, FBXW7, FLT3, HRAS, JAK1, JAK2, JAK3, KMT2A, KRAS, MYC, NOTCH1, NRAS, PTEN, PTPN11, RUNX1 (AML1), SF3B1, TP53 (p53)
Acute Myeloid Leukemia (AML)
ASXL1, ATRX, BRCA1, BRCA2, CBLB, CBLC, CEBPA, DNMT3A, ETV6, FLT3, GATA1, GATA2, GNAS, HRAS, IDH1, IDH2, JAK2, KIT (CD117), KMT2A, KRAS, MTOR, NPM1, NRAS, PDGFRA, PTPN11, RUNX1 (AML1), SF3B1, SMC1A, TET2, TP53 (p53), U2AF1, WT1
Acute Promyelocytic Leukemia (APML; APL)
CEBPA, NPM1, RUNX1 (AML1)
Atypical Chronic Myeloid Leukemia (aCML)
ASXL1, CBL, CEBPA, EZH2, FLT3, JAK2, KRAS, NPM1, NRAS, RUNX1 (AML1), SETBP1, SRSF2, TET2, U2AF1
Chronic Lymphocytic Leukemia (CLL)
ATRX, BCL2, BRAF, CBLB, GNAS, GNB1, MYD88, NOTCH1, NRAS, PTPN11, SF3B1, TP53 (p53), XPO1
Chronic Myeloid Leukemia (CML)
ABL1, ASXL1, BCOR, BRAF, CBL, CREBBP (CBP), DNMT3A, EZH2, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1 (AML1), TET2, TP53 (p53), WT1
Chronic Myelomonocytic Leukemia (CMML)
ASXL1, BCOR, BCORL1, CBL, CEBPA, DNMT3A, EZH2, FLT3, IDH1, IDH2, JAK2, KIT (CD117), KRAS, MPL, NF1, NPM1, NRAS, PHF6, PTPN11, RUNX1 (AML1), SETBP1, SF3B1, SRSF2, STAG2, TET2, TP53 (p53), U2AF1, ZRSR2
Hairy Cell Leukemia
BRAF, TP53 (p53)
Juvenile Myelomonocytic Leukemia
CBL, KRAS, NRAS, PTPN11
Lymphomas
Acute Lymphocytic Lymphomas
BTK, CDKN2A (P16INK4A), MYC, NOTCH1, SF3B1, TP53 (p53)
B Cell Lymphomas
BCL6, BRAF, CHEK2 (RAD53), EZH2, MYD88, TP53 (p53)
Burkitt Lymphomas
CBLB, GNA13, MTOR, MYC
Diffuse Large B Cell Lymphomas
B2M, BCL2, CBLB, GNA13, KMT2D, MTOR, PIM1, SOCS1, TNFAIP3
Follicular Lymphomas
ARID1A, BCL2, CARD11, CREBBP (CBP), EZH2, KMT2D
Mantle Cell Lymphomas
ATM
Marginal Zone Lymphomas
MYD88, TNFAIP3, TP53 (p53)
Mucosa-Associated Lymphoid Tissue (MALT) Lymphomas
TNFAIP3
Non-Hodgkin Lymphomas
BRAF, NRAS, PIK3CA (p110-alpha), TP53 (p53)
Primary Cutaneous Lymphomas
CD79B, MYD88
Small Lymphocytic Lymphomas
ATRX, BCL2, CBLB, GNAS, XPO1
T Cell Lymphomas
ATM, CBLB, DNMT3A, IDH1, IDH2, JAK1, JAK3, RHOA, STAT3, STAT5B, TET2
Myelodysplastic Syndromes & Myeloproliferative Neoplasms
Myelodysplastic Syndromes
ASXL1, ATRX, BCOR, BCORL1, CALR, CBL, CEBPA, CSF3R (GM-CSFR), DNMT3A, ETV6, EZH2, FLT3, GATA2, GNAS, GNB1, IDH1, IDH2, JAK2, JAK3, KIT (CD117), KRAS, MPL, NF1, NPM1, NRAS, PHF6, PPM1D, PTPN11, RAD21, RUNX1 (AML1), SETBP1, SF3B1, SMC3, SRSF2, STAG2, STAT3, TET2, TP53 (p53), U2AF1, WT1, ZRSR2
Myeloproliferative Neoplasms
ASXL1, CALR, CBL, DNMT3A, EZH2, IDH1, IDH2, JAK2, MPL, RUNX1 (AML1), SF3B1, SRSF2, TP53 (p53), U2AF1
Other Myeloid Neoplasms
Essential Thrombocythemia
ASXL1, CBL, IDH2, JAK2, MPL, SF3B1, TET2, TP53 (p53)
Multiple Myeloma
ATM, BARD1, BRAF, BRCA1, BRCA2, BRIP1, CHEK1, CHEK2 (RAD53), EGFR (ERBB1), ERBB2 (HER-2, NEU), FANCL, FGFR3, IDH1, IDH2, KIT (CD117), KRAS, MET, NRAS, PALB2, PDGFRA, RAD51B, RAD51C, RAD51D, RET, TP53 (p53)
Plasma Cell Myeloma
HRAS, MTOR
Polycythemia Vera
ASXL1, DNMT3A, EZH2, IDH1, JAK2, NRAS, TET2, TP53 (p53)
Primary Myelofibrosis
ASXL1, CBL, DNMT3A, EZH2, IDH1, IDH2, JAK2, MPL, NF1, NRAS, SETBP1, SF3B1, SRSF2, TET2, TP53 (p53)
Systemic Mastocytosis
ASXL1, CBL, DNMT3A, ETV6, EZH2, IDH2, JAK2, KIT (CD117), KRAS, NPM1, NRAS, RUNX1 (AML1), SETBP1, SF3B1, SRSF2, TET2, U2AF1
Waldenstrom Macroglobulinemia
MYD88