ILF3 Gene Summary [Human]
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014]
Details
| Type | Protein Coding |
| Official Symbol | ILF3 |
| Official Name | interleukin enhancer binding factor 3 [Source:HGNC Symbol;Acc:HGNC:6038] |
| Ensembl ID | ENSG00000129351 |
| Bio databases IDs | |
| Aliases | interleukin enhancer binding factor 3, M-phase phosphoprotein 4, nuclear factor of activated T-cells 90 kDa, nuclear factor of activated T-cells 110 kDa, translational control protein 80, double-stranded RNA-binding protein, 76 kD, M phase phosphoprotein 4, nuclear factor associated with DS RNA, dsRNA binding protein NFAR-2/MPP4 |
| Synonyms | CBTF, DRBF, Interleukin binding factor 3, interleukin enhancer binding factor 3, MBII-26, MMP4, MPHOSPH4, MPP4, MPP4110, NF90, NFAR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ILF3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DZF domain
- transcription regulator
- mRNA 3' UTR binding
- Double-stranded RNA binding motif
- viral receptor
- double-stranded RNA binding motif (DSRM) superfamily
- double-stranded RNA binding
- enzyme binding
- protein binding
- dsRNA-binding domain
- transcription factor activity
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- cyanosis
- systemic lupus erythematosus
- neoplasia
- stroke
- breast cancer
- ischemic stroke
role in cell
- expression in
- transactivation in
- binding in
- apoptosis
- growth
- proliferation
- phosphorylation in
- migration
- survival
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cell surface
- ribosome
- Mitochondria
- cytosol
- nucleoplasm
- nucleoli
- interchromatin granule clusters
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ILF3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- defense response to virus
- protein phosphorylation
- negative regulation of viral genome replication
- negative regulation of translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- mitochondrion
- cytosol
- extracellular region
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA binding
- mRNA 3'-UTR AU-rich region binding
- double-stranded RNA binding
- single-stranded RNA binding
- viral receptor activity