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miRNA Functional Analysis

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Multiple approaches to determine miRNA function

The high degree of similarity between miRNA sequences makes studying them difficult, but we have enhanced our miRCURY miRNA functional analysis tools with locked nucleic acids (LNA) to increase the discrimination of closely related sequences. Our tools help you study miRNA function using a variety of approaches.

The miRNA inhibitors specifically suppress miRNA activity and can help you determine the role of miRNAs in cellular processes and pathological pathways or identify and validate miRNA targets.

The miRNA mimics simulate the natural functions of endogenous miRNAs and are primarily used in gain-of-function studies. You can use mimics to study the effect of increasing the cellular content of a miRNA via cellular assays to monitor cell proliferation, cell differentiation, or apoptosis. You can also measure gene expression at the mRNA or protein level of putative miRNA targets.

The miRNA target site blockers (TSBs) effectively block the interaction of a miRNA with a specific target site, without affecting the activity of the miRNA. This lets you investigate the contribution of an individual target to an observed phenotype.

Related Applications and Insights

LNA technology center
LNA technology center
Discover how the high affinity of locked nucleic acids (LNA) to their targets helps overcome the difficulties of studying very short DNA and RNA fragments
Learn more
miRNA inhibitor custom builder
miRNA inhibitor custom builder
This user-friendly builder lets you create and order custom antisense sterical blockers to inhibit miRNAs as well as short ncRNAs not in miRBase
Learn more

Products (6)

Species
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Product Type
miRNA Inhibitors
miRCURY LNA miRNA Family Power InhibitorsmiRCURY LNA miRNA Family Power Inhibitors

For miRNA loss-of-function studies using LNA-enhanced antisense miRNA inhibitors

Customizable
Custom miRCURY LNA Inhibitors and Power InhibitorsCustom miRCURY LNA Inhibitors and Power Inhibitors

For miRNA function studies using LNA-enhanced antisense miRNA inhibitors

miRCURY LNA miRNA Inhibitors and Power InhibitorsmiRCURY LNA miRNA Inhibitors and Power Inhibitors

For miRNA loss-of-function studies using LNA-enhanced antisense miRNA inhibitors

miRNA Mimics
miRCURY LNA miRNA MimicsmiRCURY LNA miRNA Mimics

For studies on miRNA function and gene regulation using synthetic miRNA

miScript miRNA MimicsmiScript miRNA Mimics

For studies on miRNA function and gene regulation using synthetic miRNA

miRNA Target Site Blockers
miRCURY LNA miRNA Power Target Site BlockersmiRCURY LNA miRNA Power Target Site Blockers

Custom-designed target site blockers for studying the effects of an individual miRNA on a single target site