mRNA & lncRNA Functional Analysis

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Efficient knock-down of mRNA and lncRNA targets

Our traditional siRNA solutions support a range of loss-of-function experiments, from the knockdown of a single gene of interest, to small numbers of related genes or genes within a common pathway, to genomewide high-throughput screens.

For particularly difficult applications, the Antisense LNA GapmeRs are an excellent alternative to siRNA. For example, many lncRNAs are confined to the nuclear compartment, where they are inefficiently targeted by siRNA. But these lncRNAs remain sensitive to LNA GapmeRs, which function by RNase H-dependent degradation of complementary RNA targets to provide strand-specific knockdown with no RISC-associated, off-target activity. The LNA GapmeRs are active in vivo and in vitro, enabling the analysis RNA function in a wide range of model systems.

Related Applications and Insights

LNA technology center
LNA technology center
Discover how the high affinity of locked nucleic acids (LNA) to their targets helps overcome the difficulties of studying very short DNA and RNA fragments
Learn more
RNA silencing custom builders
RNA silencing custom builders
Create and order custom LNA GapmeRs and siRNAs that specifically and effectively knock down your targets of interest in RNA silencing experiments
Learn more

Products (9)

Product Type
Antisense LNA GapmeRs
Antisense LNA GapmeRsAntisense LNA GapmeRs

LNA-enhanced antisense oligonucleotides for highly effective knockdown of mRNA and lncRNA

AllStars Hs Cell Death Control siRNAAllStars Hs Cell Death Control siRNA

For siRNA transfection optimization and positive control experiments in human cells

AllStars Mm/Rn Cell Death Control siRNAAllStars Mm/Rn Cell Death Control siRNA

For siRNA transfection optimization and positive control experiments in mouse or rat cells

AllStars Negative Control siRNAAllStars Negative Control siRNA

For negative control RNAi experiments

AllStars Reporter ControlsAllStars Reporter Controls

For knockdown of a reporter gene

FlexiPlate siRNAFlexiPlate siRNA

For highly flexible, economical RNAi screening

FlexiTube siRNAFlexiTube siRNA

For efficient RNAi analysis one gene at a time

FlexiTube siRNA PremixFlexiTube siRNA Premix

For optimized, one-step siRNA transfection

HP Custom siRNAHP Custom siRNA

For efficient gene silencing using high-purity siRNA