Our collection of predesigned miRCURY LNA miRNA Detection Probes covers most known invertebrate, vertebrate and plant miRNAs that are annotated in miRbase, and we offer the possibility to create your own custom probes for analysis of novel targets. The probes are designed with optimal LNA positioning for high sequence specificity, low secondary structure and minimal self-annealing.
The resulting superior binding affinity lets you specifically and sensitively detect any miRNA with an exceptionally high signal-to-noise ratio via in situ hybridization (ISH) and Northern blotting experiments. The probes can be used for a large number of applications, including cellular and sub-cellular miRNA localization studies and determination of spatial miRNA expression. The robustness of the procedure makes them a great tool for use in both high-throughput ISH analysis and localization studies of individual miRNAs.