Target List
Senescence Pathway
Atm, Bmi1, Ccnd1, Ccne1, Cdk2, Cdk4, Cdk6, Cdkn1a (p21cip1, Waf1), Chek1, Chek2 (Rad53), E2f1, E2f3, Ets1, Ets2, Cdkn2a (Cdkn2a, p16ink4a), Mdm2, Rb1, Rbl2, Tp53 (p53), Twist1
Senescence Initiators
p53 Signaling​
Abl1
p53 / pRb Signaling & the Cell Cycle​
Akt1, Aldh1a3 (Raldh3), Ccna2, Ccnb1, Cdc25b, Cdc25c, Cdkn1c (p57kip2), Cdkn2c (p18-Ink4c), Cited2, Creg1, Gsk3b, Id1, Igf1r, Igfbp3, Ing1, LOC100758352 (Myc), Map2k6 (Mek6, Mkk6), Mapk14 (p38alpha), Morc3, Pcna, Pik3ca (p110alpha), Plau (Upa), Rbl1, Serpinb2 (Pai-2), Serpine1 (Pai-1), Sirt1, Sparc, Tgfb1
Interferon Signaling​
Aldh1a3 (Raldh3), Cdkn1a (p21cip1, Waf1), Cdkn1b (p27kip1), Egr1, Ifng, Igfbp3, Igfbp7, Irf3, Irf5, Irf7, Nfkb1 (Nfkb1), Rb1, Serpinb2 (Pai-2)
Insulin Growth Factor (IGF) Related​
Igf1, Igf1r, Igfbp3, Igfbp5, Igfbp7
MAP Kinase Signaling​
Hras, Map2k1, Map2k3 (Mek3), Map2k6 (Mek6, Mkk6), Mapk14 (p38alpha)
Oxidative Stress​
Aldh1a3 (Raldh3), Hras, Mapk14 (p38alpha), Nox4, Prkcd, Sod1, Sod2
DNA Damage & Repair​
Atm, LOC103159266 (Gadd45a), Nbn, Pcna, Terf2, Tert, Tp53bp1
Senescence Responses
p53 Effectors​
Aldh1a3 (Raldh3), E2f1, Hras, Igfbp3, LOC100758352 (Myc)
p21 Effectors​
Calr
p16 Effectors​
Tbx2, Tbx3
Cytoskeleton Regulators​
Akt1, Fn1, Hras, Pik3ca (p110alpha), Plau (Upa), Serpine1 (Pai-1), Sparc, Thbs1 (Tsp-1), Vim
Cell Adhesion Molecules​
Cd44, Col1a1, Col3a1, Tgfb1, Tgfb1i1, Thbs1 (Tsp-1)
Other Senescence Response Genes​
Glb1, Necdin, Pten