Target List
Senescence Pathway
AtmBmi1Ccnd1Ccne1Cdk2Cdk4Cdk6Cdkn1a (p21cip1, Waf1)Chek1Chek2 (Rad53)E2f1E2f3Ets1Ets2Cdkn2a (Cdkn2a, p16ink4a)Mdm2Rb1Rbl2Tp53 (p53)Twist1
Senescence Initiators
p53 Signaling
Abl1
p53 / pRb Signaling & the Cell Cycle
Akt1Aldh1a3 (Raldh3)Ccna2Ccnb1Cdc25bCdc25cCdkn1c (p57kip2)Cdkn2c (p18-Ink4c)Cited2Creg1Gsk3bId1Igf1rIgfbp3Ing1LOC100758352 (Myc)Map2k6 (Mek6, Mkk6)Mapk14 (p38alpha)Morc3PcnaPik3ca (p110alpha)Plau (Upa)Rbl1Serpinb2 (Pai-2)Serpine1 (Pai-1)Sirt1SparcTgfb1
Interferon Signaling
Aldh1a3 (Raldh3)Cdkn1a (p21cip1, Waf1)Cdkn1b (p27kip1)Egr1IfngIgfbp3Igfbp7Irf3Irf5Irf7Nfkb1 (Nfkb1)Rb1Serpinb2 (Pai-2)
Insulin Growth Factor (IGF) Related
Igf1Igf1rIgfbp3Igfbp5Igfbp7
MAP Kinase Signaling
HrasMap2k1Map2k3 (Mek3)Map2k6 (Mek6, Mkk6)Mapk14 (p38alpha)
Oxidative Stress
Aldh1a3 (Raldh3)HrasMapk14 (p38alpha)Nox4PrkcdSod1Sod2
DNA Damage & Repair
AtmLOC103159266 (Gadd45a)NbnPcnaTerf2TertTp53bp1
Senescence Responses
p53 Effectors
Aldh1a3 (Raldh3)E2f1HrasIgfbp3LOC100758352 (Myc)
p21 Effectors
Calr
p16 Effectors
Tbx2Tbx3
Cytoskeleton Regulators
Akt1Fn1HrasPik3ca (p110alpha)Plau (Upa)Serpine1 (Pai-1)SparcThbs1 (Tsp-1)Vim
Cell Adhesion Molecules
Cd44Col1a1Col3a1Tgfb1Tgfb1i1Thbs1 (Tsp-1)
Other Senescence Response Genes
Glb1NecdinPten