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LNA Oligo Optimizer

LNA-enhanced oligonucleotides have different thermodynamic properties from traditional DNA oligonucleotides and will thus fold differently. This tool calculates scores for self-complementarity and secondary structure of an LNA-enhanced oligonucleotide. These scores can be used as a rough estimate of the temperature at which an oligonucleotide will form secondary structure and self-complementarity


Please use these base codes: DNA bases: A, C, G, T. Locked nucleic acid bases (LNA) are entered as '+' followed by the base (example: +A)

Use FASTA format
LNA Oligo Optimizer