PTGES
PTGES Gene Summary
The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | PTGES |
| Official Name | prostaglandin E synthase [Source:HGNC Symbol;Acc:HGNC:9599] |
| Ensembl ID | ENSG00000148344 |
| Bio databases IDs | |
| Aliases | prostaglandin E synthase, microsomal glutathione S-transferase 1-like 1, tumor protein p53 inducible protein 12, p53-induced gene 12, microsomal prostaglandin E synthase-1, glutathione S-transferase 1-like 1, MGST1-like 1 |
| Synonyms | 2410099E23Rik,CPGES,D2Ertd369e,MGST1-L1,MGST-IV,MPGES,MPGES-1,PGES,PGES1,PIG12,PP102,PP1294,prostaglandin E synthase,PTGES1,TP53I12 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- glutathione transferase
- MAPEG family
- enzyme
- protein binding
- Glutathione acceptor domain
- glutathione peroxidase
- prostaglandin-D synthase
- prostaglandin-E synthase
Pathways
Biological processes and signaling networks where the PTGES gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- PLP2
- CFTR
- TMEM222
- vipoglanstat
- zaloglanstat
- ARLN
- PTGES
- TGOLN2
- GAG
- EGR1
disease
- hypertension
- neoplasia
- experimental autoimmune encephalomyelitis
- organismal death
- rheumatoid arthritis
- diastolic dysfunction
- serous ovarian cancer
- chronic inflammation
- abdominal aortic aneurysm
- non-small cell lung carcinoma
regulated by
- TGFB1
- exisulind
- cisplatin
- EGFR
- IL1B
- IL6
- EGF
- lipopolysaccharide
- SPOP
- norepinephrine
regulates
- CDKN1A
- Collagen(s)
- MYH6
- PTGS2
- VIM
- EZR
- CCL2
- TNF
- IL1B
- IL6
role in cell
- accumulation in
- expression in
- proliferation
- quantity
- apoptosis
- colony formation
- number
- cellular infiltration by
- hypertrophy
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- lipid-rich fraction
- perinuclear membrane
- perinuclear region
- cellular membrane
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- perinuclear space
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PTGES gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of prostaglandin secretion
- cell proliferation
- signal transduction
- negative regulation of cell proliferation
- prostaglandin biosynthetic process
- sensory perception of pain
- regulation of inflammatory response
- prostaglandin metabolic process
- regulation of fever generation
CELLULAR COMPONENT
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- perinuclear region of cytoplasm
- membrane
- nuclear envelope lumen
MOLECULAR FUNCTION
What the gene product does at the molecular level
- prostaglandin-D synthase activity
- protein binding
- glutathione peroxidase activity
- glutathione binding
- prostaglandin-E synthase activity
- glutathione transferase activity