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p53 Signaling | GeneGlobe

p53 Signaling


Pathway Description

The p53 (TP53) tumor suppressor protein is a key transcriptional regulator that responds to a variety of cellular stresses such as DNA damage, UV irradiation, and hypoxia. p53 regulates key cellular processes such as DNA repair, cell-cycle progression, angiogenesis, and apoptosis. These p53-dependent pathways shut down damaged cells, either through apoptosis or cell-cycle arrest. Loss of p53 function is thought to be a contributing factor in the majority of cancer cases.