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Polyamines are vital for the growth and function of normal cells. The amino acid-derived polyamines like putrescine, spermidine and spermine that are the main polyamines found in prokaryotes and eukaryotes have long been associated with cell growth and cancer. Specific oncogenes and tumor suppressor genes regulate polyamine metabolism. Regulation of these polyamines is chiefly associated with cancers pertaining to the colon. Polyamines are formed by the enzymatic decarboxylation of amino acids like ornithine or arginine by ornithine decarboxylase-1 (ODC1), the enzyme required for the first stage in polyamine synthesis...