Krt14

Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including establishment of skin barrier; keratinization; and keratinocyte migration. Predicted to act upstream of or within intermediate filament cytoskeleton organization. Predicted to be located in intermediate filament. Predicted to be active in cornified envelope. Biomarker of esophagus squamous cell carcinoma. Human ortholog(s) of this gene implicated in ectodermal dysplasia; focal nonepidermolytic palmoplantar keratoderma 1; and pachyonychia congenita. Orthologous to human KRT16 (keratin 16). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Krt14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Krt14 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.