Mrgprb2 Gene Summary [Mouse]
Predicted to enable G protein-coupled receptor activity and neuropeptide binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Orthologous to human MRGPRX2 (MAS related GPR family member X2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mrgprb2 |
| Official Name | MAS-related GPR, member B2 [Source:MGI Symbol;Acc:MGI:2441674] |
| Ensembl ID | ENSMUSG00000050425 |
| Bio databases IDs | |
| Aliases | MAS-related GPR, member B2 |
| Synonyms | 4833406I20Rik, MAS-related GPR, member B2, Mgrg10, Mgrg14, MrgB6, Mrgprb6, Mrgprx1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mrgprb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- neuropeptide binding
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- mechanical hypersensitivity
- thermal hyperalgesia
regulated by
- compound 48/80
- vancomycin
regulates
- histamine
- Evans Blue
role in cell
- activation
- degranulation
- infiltration by
- degranulation in
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane