Ahsp Gene Summary [Rat]
This gene encodes a molecular chaperone which binds specifically to free alpha-globin and is involved in hemoglobin assembly. The encoded protein binds to monomeric alpha-globin until it has been transferred to beta-globin to form a heterodimer, which in turn binds to another heterodimer to form the stable tetrameric hemoglobin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | Ahsp |
| Official Name | alpha hemoglobin stabilizing protein [Source:RGD Symbol;Acc:1306725] |
| Ensembl ID | ENSRNOG00000020165 |
| Bio databases IDs | |
| Aliases | alpha hemoglobin stabilizing protein |
| Synonyms | alpha haemoglobin stabilizing protein, alpha hemoglobin stabilizing protein, EDRF, ERAF, Erythroid differentiatiation factor, α haemoglobin stabilizing protein, α hemoglobin stabilizing protein |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ahsp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Alpha-haemoglobin stabilising protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- leptocytosis
- anemia
- anisopoikilocytosis
- beta thalassemia
- acanthocytosis
- proliferative diabetic retinopathy
- anisocytosis
regulates
- reactive oxygen species
- hemoglobin alpha
- hemoglobin
role in cell
- differentiation
- apoptosis
- number
- damage
- abnormal morphology
- morphology
- formation
- presence
- quantity
- sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ahsp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- erythrocyte differentiation
- hemopoiesis
- protein stabilization
- protein folding
- hemoglobin metabolic process
Cellular Component
Where in the cell the gene product is active
- hemoglobin complex
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- hemoglobin binding
- unfolded protein binding