Haao Gene Summary [Rat]
Enables 3-hydroxyanthranilate 3,4-dioxygenase activity; iron ion binding activity; and oxygen binding activity. Involved in quinolinate metabolic process. Located in mitochondrial membrane. Used to study Huntington's disease. Orthologous to human HAAO (3-hydroxyanthranilate 3,4-dioxygenase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Haao |
| Official Name | 3-hydroxyanthranilate 3,4-dioxygenase [Source:RGD Symbol;Acc:71071] |
| Ensembl ID | ENSRNOG00000031263 |
| Bio databases IDs | |
| Aliases | 3-hydroxyanthranilate 3,4-dioxygenase |
| Synonyms | 0610007K21Rik, 0610012J07Rik, 3-HAO, 3-HAOxase, 3-hydroxyanthranilate 3,4-dioxygenase, 3-hydroxyanthranilate 34-dioxygenase, 3-hydroxyanthranilate oxygenase, 3-HYDROXYANTHRANILIC ACID OXYGENASE, h3HAO, HAO, VCRL1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Haao often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ferrous iron binding
- oxygen binding
- iron ion binding
- enzyme
- protein binding
- Cupin domain
- 3-hydroxyanthranilate 3,4-dioxygenase
- RmlC-like cupin superfamily
Pathways
Biological processes and signaling networks where the Haao gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- vertebral, cardiac, renal and limb defects syndrome 1
- androgenic alopecia
- sporadic amyotrophic lateral sclerosis
- hypospadia
- diabetic nephropathy
regulates
- NAD+
- quinolinic acid
- 3-hydroxyanthranilic acid
- alpha-amino-omega-carboxymuconic acid semialdehyde
- 2-amino-3-carboxymuconate semialdehyde
role in cell
- homeostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- mitochondrial membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Haao gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tryptophan catabolic process
- quinolinate biosynthetic process
- neuron homeostasis
- response to zinc ion
- de novo NAD biosynthetic process from tryptophan
- anthranilate metabolic process
- NAD biosynthetic process
- response to cadmium ion
- quinolinate metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- ferrous iron binding
- electron carrier activity
- 3-hydroxyanthranilate 3,4-dioxygenase activity