Ifng Gene Summary [Rat]
Enables cytokine activity. Involved in several processes, including negative regulation of cell population proliferation; positive regulation of cell communication; and regulation of macromolecule biosynthetic process. Located in extracellular space and perikaryon. Used to study several diseases, including Chagas disease; allergic conjunctivitis; allergic rhinitis; renal fibrosis; and ureteral obstruction. Biomarker of several diseases, including artery disease (multiple); autoimmune thyroiditis; obesity; pulpitis; and tongue squamous cell carcinoma. Human ortholog(s) of this gene implicated in several diseases, including ataxia telangiectasia; autoimmune disease (multiple); eczema herpeticum; factor VIII deficiency; and leukemia (multiple). Orthologous to human IFNG (interferon gamma). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ifng |
| Official Name | interferon gamma [Source:RGD Symbol;Acc:2866] |
| Ensembl ID | ENSRNOG00000007468 |
| Bio databases IDs | |
| Aliases | interferon gamma |
| Synonyms | If2f, IFG, IFI, IFN-2, IFNG2, IFN gamma, IFN-II, IFN type II, IFN-γ, IMD69, INF-γ, Interferon gamma, Interferon γ, type II INTERFERON, γ-ifn, γ interferon |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ifng often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interferon-gamma receptor binding
- protein binding
- cytokine
- basic domain
- Interferon gamma
Pathways
Biological processes and signaling networks where the Ifng gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Allograft Rejection Signaling
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- Antigen Presentation Pathway
- Atherosclerosis Signaling
- Colorectal Cancer Metastasis Signaling
- Communication between Innate and Adaptive Immune Cells
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F
- Erythropoietin Signaling
- Glucocorticoid Receptor Signaling
- Graft-versus-Host Disease Signaling
- Hepatic Cholestasis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HMGB1 Signaling
- IL-10 Signaling
- IL-17 Signaling
- IL-7 Signaling Pathway
- iNOS Signaling
- Interferon Signaling
- MSP-RON Signaling Pathway
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- Th2 Pathway
- VDR/RXR Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight loss
- infection
- hypersensitive reaction
- epithelial cancer
- epithelial neoplasia
- cancer
- digestive system cancer
- abdominal cancer
- neoplasia
- autoimmune disease
phenotypes
- Acute Lung Injury
- Alcoholic Intoxication
- B-Cell Chronic Lymphocytic Leukemia
- Behcet's disease
- Bronchial Hyperreactivity
- Chagas Disease
- Chronic Pancreatitis
- Chronic Thyroiditis
- Corneal Perforation
- Delayed Hypersensitivity
- Diabetes Mellitus Experimental
- Diabetic Nephropathies
- Endotoxemia
- Experimental Arthritis
- Experimental Autoimmune Encephalomyelitis
- Experimental Autoimmune Uveoretinitis
- Experimental Colitis
- Experimental Sarcoma
- Fanconi Anemia
- Graft vs Host Disease
- Graves Ophthalmopathy
- Graves Disease
- Hashimoto Disease
- Inflammation
- Kidney Calculi
- Mycobacterium Infections
- Mycoplasma pneumoniae pneumonia
- Nasal Polyps
- Otitis Media with Effusion
- Polymyositis
- Reperfusion Injury
- Shock Hemorrhagic
- Sjogren's Syndrome
- Transplant Rejection
- Viral Myocarditis
- Vogt-Koyanagi-Harada disease
- acute disseminated encephalomyelitis
- acute retinal necrosis syndrome
- adult T-cell leukemia
- allergic conjunctivitis
- allergic rhinitis
- anterior uveitis
- aplastic anemia
- asthma
- Ataxia Telangiectasia
- atopic dermatitis
- autoimmune thyroiditis
- breast cancer
- Bronchitis
- cataract
- Choroiditis
- chronic granulomatous disease
- dermatomyositis
- diabetic neuropathy
- disease of cellular proliferation
- dry eye syndrome
- eczema herpeticum
- Endophthalmitis
- factor VIII deficiency
- genital herpes
- Glomerulonephritis
- Glucosephosphate Dehydrogenase Deficiency
- Hemorrhagic Fever with Renal Syndrome
- herpes simplex virus keratitis
- Leishmaniasis
- Lichen Planus
- Liver Cirrhosis
- Lupus Nephritis
- malignant glioma
- Mixed Connective Tissue Disease
- Multiple Sclerosis
- myeloid leukemia
- Nephritis
- obesity
- Otitis Media
- pancreatic cancer
- Panuveitis
- precursor lymphoblastic lymphoma/leukemia
- Pulpitis
- relapsing polychondritis
- Renal Fibrosis
- respiratory syncytial virus infectious disease
- rheumatoid arthritis
- selective IgG deficiency disease
- sensorineural hearing loss
- Status Asthmaticus
- suppurative otitis media
- systemic lupus erythematosus
- systemic scleroderma
- temporal arteritis
- tongue squamous cell carcinoma
- type 1 diabetes mellitus
- type 2 diabetes mellitus
- Ureteral Obstruction
- urinary bladder cancer
- Uveitis
- vesicoureteral reflux
- visceral leishmaniasis
- visual epilepsy
- Vitiligo
- Hemorrhagic Shock
- Hepatitis B Chronic
- Intestinal Helminthiasis
- Kidney Reperfusion Injury
- Brucellosis
- chromoblastomycosis
- Dyspepsia
- Endometriosis
- inflammatory bowel disease
- Tularemia
- Hantavirus hemorrhagic fever with renal syndrome
- Chronic Hepatitis B
- acute lymphoblastic leukemia
- Coronavirus infectious disease
- Middle East respiratory syndrome
- Severe Acute Respiratory Syndrome
- Experimental Diabetes Mellitus
- Helicobacter Infections
- Streptococcus pneumonia
- abdominal aortic aneurysm
- bacterial pneumonia
- Hypothyroidism
- lung disease
- primary biliary cholangitis
- toxic shock syndrome
- viral hepatitis
role in cell
- cell death
- binding
- expression in
- phosphorylation in
- formation
- formation in
- inhibition
- acidification
- upregulation in
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- cell periphery
- intracellular space
- membrane surface
- apical cell surfaces
- plasma membrane extracellular face
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ifng gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of smooth muscle cell apoptotic process
- positive regulation of peptidyl-serine phosphorylation of STAT protein
- macrophage activation involved in immune response
- positive regulation of tyrosine phosphorylation of STAT protein
- JAK-STAT cascade
- regulation of insulin secretion
- negative regulation of transcription, DNA-dependent
- positive regulation of membrane protein ectodomain proteolysis
- humoral immune response
- apoptotic process
- defense response to virus
- positive regulation of tumor necrosis factor production
- positive regulation of chemokine production
- macrophage differentiation
- positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity
- positive regulation of protein import into nucleus
- positive regulation of fructose 1,6-bisphosphate metabolic process
- positive regulation of inflammatory response
- negative regulation of beta-amyloid clearance
- positive regulation of calcidiol 1-monooxygenase activity
- adaptive immune response
- positive regulation of vitamin D biosynthetic process
- positive regulation of autophagy
- negative regulation of gene expression
- negative regulation of epithelial cell differentiation
- positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of gene expression
- positive regulation of neurogenesis
- positive regulation of interleukin-6 production
- positive regulation of phagocytosis
- positive regulation of nitric oxide biosynthetic process
- positive regulation of protein deacetylation
- positive regulation of cell proliferation
- extrinsic apoptotic signaling pathway
- response to virus
- positive regulation of glycolysis
- positive regulation of MHC class II biosynthetic process
- negative regulation of transcription from RNA polymerase II promoter
- astrocyte activation
- positive regulation of interleukin-23 production
- positive regulation of osteoclast differentiation
- negative regulation of smooth muscle cell proliferation
- regulation of metabolic process
- positive regulation of epithelial cell migration
- negative regulation of interleukin-17 production
- positive regulation of protein complex assembly
- interferon-gamma-mediated signaling pathway
- positive regulation of receptor activity
- cell surface receptor signaling pathway
- microglial cell activation
- positive regulation of interleukin-12 production
- positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
- positive regulation of killing of cells of other organism
- positive regulation of cytokine production
- positive regulation of protein serine/threonine kinase activity
- positive regulation of interleukin-1 beta production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- interferon-gamma receptor binding
- cytokine activity