GNAS-AS1 Gene Summary [Human]
This gene produces a paternally-imprinted antisense RNA transcript that helps regulate the GNAS complex locus, which encodes the alpha subunit of the stimulatory G protein. Defects in this gene are a cause of pseudohypoparathyroidism type Ib.[provided by RefSeq, Jun 2010]
Details
| Type | Long Non-Coding RNA |
| Official Symbol | GNAS-AS1 |
| Official Name | GNAS antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:24872] |
| Ensembl ID | ENSG00000235590 |
| Bio databases IDs | |
| Aliases | GNAS antisense RNA 1, GNAS antisense, non-protein coding RNA 75 |
| Synonyms | GNAS1AS, GNAS antisense RNA 1, GNAS-AS, NCRNA00075, NESP-AS, SANG |
| Species | Human, Homo sapiens |
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- STAT3
- miR-433-3p (miRNAs w/seed UCAUGAU)
disease
- acute myeloid leukemia
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- keloid
- chronic lymphocytic leukemia
- osteoarthritis
- pseudohypoparathyroidism type 1B
- estrogen receptor positive breast cancer
role in cell
- proliferation
- expression in
- migration
- invasion by
- cell proliferation
- M2 polarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown