Target List
Caspases & Regulators
Caspases
CARD17, CARD18, CASP1 (ICE), CASP10 (MCH4), CASP14, CASP2, CASP3, CASP4, CASP5, CASP6, CASP7, CASP8 (FLICE), CASP9, CFLAR (CASPER), CRADD, MALT1, PYCARD (TMS1, ASC), COP1
Caspase Activation
AIFM3, APAF1, BAX, BBC3 (PUMA), BCL2L10, BCL2L13, CASP1 (ICE), CASP8AP2, CASP9, COL4A3, CYCS, DIABLO, EIF2AK3, F2 (Thrombin), F2R (PAR1), FOXL2, HIP1, HSPE1, IFNB1, IFT57, LCK, MAP3K5, MOAP1, MTCH1, MYC, NLRC4 (IPAF), NLRP1, NLRP12, NLRP2, NLRP3, NOD1 (CARD4), PMAIP1 (NOXA), PYCARD (TMS1, ASC), STAT1, TNFRSF10A (TRAIL-R), TNFRSF10B (DR5), TNFSF15, TP53 (p53), TPD52L1, VCP
Caspase Inhibition
BIRC5, CD27 (TNFRSF7), DHCR24, IFI6, LAMTOR5, SFN (14-3-3σ, YWHAS), TNFAIP8, TNFSF14, TRIAP1, XIAP
Anti-Apoptotic
Positive Regulation of Anti-Apoptosis
BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), BRE, CD28, ERC1, MAPK8IP2 (JIP-1), OPA1, PRKAA1 (AMPK), RASA1
Negative Regulation of Anti-Apoptosis
PIK3R2 (p85-BETA), RTN4, TNFAIP8
Other Anti-Apoptotic Genes
AATF, AKT1, ALOX12, ANXA1, ANXA4, API5, ATF5, AVEN, AZU1, BAG1, BAG3, BAG4, BCL2, BCL2A1 (BFL1), BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L10, BCL2L2, BDNF, BECN1, BFAR, BIRC2 (c-IAP1), BIRC3 (c-IAP2), BIRC5, BIRC6, BIRC7, BIRC8, BNIP1, BNIP2, BNIP3, BRAF, CASP2, CBX4, CCL2 (MCP-1), CD27 (TNFRSF7), CD40LG, CEBPB, CFDP1, CFL1, CFLAR (CASPER), CRYAA, CRYAB, DAD1, DDAH2, DHCR24, EEF1A2, FAIM, FAIM2, FAS, FOXO1, GDNF, GFRAL, GLO1, GSTP1, HDAC1, HDAC3, HIPK3, HMGB1, HSP90B1, HSPA1B, HSPA9, HSPB1 (HSP27), HTATIP2, HTT, IER3, IFI6, IGF1R, IL10, IL1A, IL2, IL31RA, LAMTOR5, MALT1, MCL1, MKL1, MPO, TESMIN, MYBL2, MYO18A, NAIP, NFKB1, NME5, NOL3, NOTCH2, NPM1, NRG2, NTF3, PAK7, PAX7, PEA15, PIK3CA (p110-alpha), PIM2, POGK, POLB, PRDX2, PRKCZ, PRLR, PROK2, PSEN1, RELA, RNF7, SEMA4D, SERPINB2 (PAI-2), SERPINB9, SFRP1, SH3GLB1, SNCA, SOCS2, SOCS3, SON, SPHK1, SPP1, STAMBP, TAX1BP1, TBX3, TGFB1, TIAF1, TMX1, TNF, TNFAIP3, TNFAIP8, TNFRSF10D, TNFRSF18, TNFRSF6B, TNFSF18, TPT1, TRIAP1, TSC22D3, VEGFA, VHL, XIAP, YWHAZ, ZC3HC1
Induction of Apoptosis
Induction of Apoptosis by Death Domain Receptors
BID, CRADD, DAXX, DEDD2, FADD, IL18, TNF, TNFRSF10B (DR5)
Induction of Apoptosis by DNA Damage
ABL1, AIFM1, BCL3, BRCA1, CHEK2 (RAD53), CIDEA, CIDEB, DYRK2, IFI16, MBD4, MSH6, PCBP4, PML, SFN (14-3-3σ, YWHAS), TP53 (p53), TP73
Induction of Apoptosis by Oxidative Stress
GPX1, PRODH, RNF7, TP53I3 (PIG3)
Induction of Apoptosis by Extracellular Signals
ADORA1, BTK, CASP8AP2, CD28, CD38, CD5, CFLAR (CASPER), DAP, DAP3, DAPK1, DPF2, FASTK, MAP3K5, NDUFA13, PDCD6, PRKCA, RIPK3, SPN, TIMP3, TNFRSF25 (DR3)
Induction of Apoptosis by Intracellular Signals
CDKN1A (p21CIP1, WAF1), CUL1, CUL2, CUL3, CUL4A, CUL5, HIPK2, MYC, SART1
Other Pro-Apoptotic Genes
ACVR1B, AIFM2, AIFM3, ALOX15B, APOE, BAD, BAK1, BAX, BBC3 (PUMA), BCL10, BCL2L11, BCL2L13, BCLAF1, BIK, BNIP1, BNIP3, BNIP3L, BOK, CASP10 (MCH4), CASP3, CASP4, CASP6, CD2, CD27 (TNFRSF7), CD70, CEBPB, CIDEC, COL4A3, DAPK2, DAPK3, DCC, DDX20, DEDD, DIABLO, EI24, ERCC2 (XPD), ERCC3 (XPB), ERN1, ERN2, FAS, FASLG (TNFSF6), FEM1B, FOXL2, FOXO3, HRK, HTATIP2, IFNA2, IFNB1, IFNG, IKBIP, IKBKG, IL19, INHA, INHBA, JMY, LALBA, LCK, LTA (TNFB), MAL, MAP3K10, MAPK1 (ERK2), MX1, NDUFS3, NGFR, NLRP1, NLRP3, NME3, NOTCH2, NOX5, NUDT2, NUPR1, PDCD5, PLAGL1, PLAGL2, PLEKHF1, PLG, PMAIP1 (NOXA), PPP1R13B, PPP2CA, PPP2R1A, PPP2R1B, PRKCE, PRKRA, PRUNE2, PTEN, PTH, PYCARD (TMS1, ASC), RPS3A, RUNX3, S100B, SAP30BP, SERINC3, SIPA1, SMNDC1, SST, SSTR3, STK17A, STK17B, TBX5, TIA1, TIAL1, TLR2, TNFRSF10A (TRAIL-R), TNFRSF19, TNFRSF9, TNFSF10 (TRAIL), TNFSF14, TNFSF8, TP53BP2, TP63, TPD52L1, TRADD, TRAF3, TRAIP, UNC13B, UTP11L, ZNF443
TNF Domain Proteins
EDA, FASLG (TNFSF6), LTA (TNFB), LTB, TNF, TNFSF10 (TRAIL), TNFSF14, TNFSF15, TNFSF8
TNFR Domain Proteins
CD27 (TNFRSF7), CD40 (TNFRSF5), FAS, LTBR, NGFR, TNFRSF10A (TRAIL-R), TNFRSF10B (DR5), TNFRSF10D, TNFRSF18, TNFRSF19, TNFRSF1A (TNFR1), TNFRSF1B, TNFRSF21, TNFRSF25 (DR3), TNFRSF6B, TNFRSF8, TNFRSF9
BCL2 & BAG Domain Proteins
BAG1, BAG3, BAG4, BAX, BCL2, BCL2A1 (BFL1), BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L10, BCL2L13, BCL2L2, MCL1
BIR Domain Proteins
BIRC2 (c-IAP1), BIRC3 (c-IAP2), BIRC5, BIRC6, BIRC7, BIRC8, NAIP, XIAP
CARD Domain Proteins
APAF1, BCL10, BIRC2 (c-IAP1), BIRC3 (c-IAP2), CARD10, CARD11, CARD14, CARD17, CARD18, CARD6, CARD9, CASP1 (ICE), CASP2, CASP4, CASP5, CASP9, CRADD, NLRP1, NOD1 (CARD4), NOD2, NOL3, PYCARD (TMS1, ASC), COP1, RIPK2
Death Domain Receptors
CRADD, DAPK1, EDAR, FADD, MALT1, NFKB1, NFKB2, NGFR, PIDD1 (PIDD), RIPK1, TNFRSF10A (TRAIL-R), TNFRSF10B (DR5), TNFRSF1A (TNFR1), TNFRSF21, TNFRSF25 (DR3), TRADD
TRAF Domain Proteins
TRAF2, TRAF3, TRAF5, TRAF7
Other Apoptosis Regulators
BCL6, CEBPG, DBP, DDIT3 (GADD153, CHOP), GRM4, LGALS1, MADD, MAPK8 (JNK1), NKX3-2, POU4F1, PROP1, RARG, STAT5A, STAT5B, TBK1, TDGF1, TRAF6, MAP3K20