Mill1 Gene Summary [Mouse]
Predicted to enable natural killer cell lectin-like receptor binding activity and receptor ligand activity. Predicted to be involved in several processes, including defense response to other organism; negative regulation of natural killer cell activation; and negative regulation of natural killer cell mediated cytotoxicity. Located in external side of plasma membrane. Orthologous to human MICA (MHC class I polypeptide-related sequence A) and MICB (MHC class I polypeptide-related sequence B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mill1 |
| Official Name | MHC I like leukocyte 1 [Source:MGI Symbol;Acc:MGI:2179988] |
| Ensembl ID | ENSMUSG00000054005 |
| Bio databases IDs | |
| Aliases | MHC I like leukocyte 1 |
| Synonyms | 5530400I18Rik, MHC I like leukocyte 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mill1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MHC-I family domain
- Class I Histocompatibility antigen, domains alpha 1 and 2
- natural killer cell lectin-like receptor binding
- immunoglobulin domain
- receptor agonist activity
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- Gstp1 (includes others)
- tetradecanoylphorbol acetate
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- plasma membrane extracellular face