Mill1 Gene Summary [Rat]
Predicted to enable natural killer cell lectin-like receptor binding activity and receptor ligand activity. Predicted to be involved in several processes, including defense response to other organism; negative regulation of natural killer cell activation; and negative regulation of natural killer cell mediated cytotoxicity. Predicted to be located in cell surface. Predicted to be active in external side of plasma membrane and extracellular space. Orthologous to human MICA (MHC class I polypeptide-related sequence A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mill1 |
| Official Name | MHC I like leukocyte 1 [Source:RGD Symbol;Acc:1311714] |
| Ensembl ID | ENSRNOG00000017699 |
| Bio databases IDs | |
| Aliases | MHC I like leukocyte 1 |
| Synonyms | 5530400I18Rik, MHC I like leukocyte 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mill1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MHC-I family domain
- Class I Histocompatibility antigen, domains alpha 1 and 2
- natural killer cell lectin-like receptor binding
- immunoglobulin domain
- receptor agonist activity
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- Gstp1 (includes others)
- tetradecanoylphorbol acetate
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- plasma membrane extracellular face