Cyp26c1 Gene Summary [Mouse]
Predicted to enable retinoic acid 4-hydroxylase activity and retinoic acid binding activity. Acts upstream of or within several processes, including anterior/posterior pattern specification; neural crest cell development; and organelle fusion. Predicted to be located in membrane. Is expressed in several structures, including alimentary system; branchial arch; epibranchial placode; future hindbrain; and inner ear. Orthologous to human CYP26C1 (cytochrome P450 family 26 subfamily C member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyp26c1 |
| Official Name | cytochrome P450, family 26, subfamily c, polypeptide 1 [Source:MGI Symbol;Acc:MGI:2679699] |
| Ensembl ID | ENSMUSG00000062432 |
| Bio databases IDs | |
| Aliases | cytochrome P450, family 26, subfamily c, polypeptide 1 |
| Synonyms | cytochrome P450 family 26 subfamily C member 1, cytochrome P450, family 26, subfamily C, polypeptide 1, EG546726, FFDD4, LOC638794 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cyp26c1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- binding protein
- retinoic acid 4-hydroxylase
- enzyme
- retinoid binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- focal facial dermal dysplasia type 4
regulated by
- alitretinoin
regulates
- tretinoin
- vitamin
- alitretinoin
role in cell
- fusion
- proliferation
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cyp26c1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- organelle fusion
- central nervous system development
- neural crest cell development
- negative regulation of retinoic acid receptor signaling pathway
- anterior/posterior pattern specification
- retinoic acid catabolic process
- vitamin metabolic process
- sterol metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- retinoic acid binding
- iron ion binding
- aromatase activity
- retinoic acid 4-hydroxylase activity
- monooxygenase activity
- heme binding