CYP26C1 Gene Summary [Human]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues. This gene is adjacent to a related gene on chromosome 10q23.33. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CYP26C1 |
| Official Name | cytochrome P450 family 26 subfamily C member 1 [Source:HGNC Symbol;Acc:HGNC:20577] |
| Ensembl ID | ENSG00000187553 |
| Bio databases IDs | |
| Aliases | cytochrome P450 family 26 subfamily C member 1 |
| Synonyms | cytochrome P450 family 26 subfamily C member 1, cytochrome P450, family 26, subfamily C, polypeptide 1, EG546726, FFDD4, LOC638794 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CYP26C1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- binding protein
- retinoic acid 4-hydroxylase
- enzyme
- retinoid binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- focal facial dermal dysplasia type 4
regulated by
- alitretinoin
regulates
- tretinoin
- vitamin
- alitretinoin
role in cell
- fusion
- proliferation
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CYP26C1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- organelle fusion
- central nervous system development
- neural crest cell development
- negative regulation of retinoic acid receptor signaling pathway
- anterior/posterior pattern specification
- retinoic acid catabolic process
- vitamin metabolic process
- sterol metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- retinoic acid binding
- iron ion binding
- aromatase activity
- retinoic acid 4-hydroxylase activity
- monooxygenase activity
- heme binding