Kcnj13 Gene Summary [Rat]

Predicted to enable inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of monoatomic ion transmembrane transport. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 16 and snowflake vitreoretinal degeneration. Orthologous to human KCNJ13 (potassium inwardly rectifying channel subfamily J member 13). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Kcnj13
Official Name
potassium inwardly-rectifying channel, subfamily J, member 13 [Source:RGD Symbol;Acc:621661]
Ensembl ID
ENSRNOG00000016057
Bio databases IDs NCBI: 94341 Ensembl: ENSRNOG00000016057
Aliases potassium inwardly-rectifying channel, subfamily J, member 13
Synonyms KIR1.4, KIR7.1, LCA16, LOC100045137, potassium inwardly rectifying channel subfamily J member 13, potassium inwardly-rectifying channel, subfamily J, member 13, SVD
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kcnj13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Inward rectifier potassium channel C-terminal domain
  • Inward rectifier potassium channel transmembrane domain
  • ion channel

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • major depression
  • leber congenital amaurosis type 16
  • peripheral snowflake retinal degeneration
  • coronary artery disease
regulated by
  • cyclic AMP
  • ESR1
  • forskolin
  • jasminoidin
  • dopamine
  • baicalin
  • cholic acid
  • PLCB3
  • Reston ebolavirus
  • Zaire ebolavirus
role in cell
  • depolarization

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cellular membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Kcnj13 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • potassium ion transport
  • regulation of ion transmembrane transport

Cellular Component

Where in the cell the gene product is active
  • ion channel complex
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • inward rectifier potassium channel activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.