Plcb3 Gene Summary [Rat]
Enables phosphatidylinositol-4,5-bisphosphate phospholipase C activity. Involved in several processes, including inositol trisphosphate metabolic process; phosphatidylinositol catabolic process; and post-Golgi vesicle-mediated transport. Located in cytosol and sarcolemma. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia with corneal dystrophy. Orthologous to human PLCB3 (phospholipase C beta 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plcb3 |
| Official Name | phospholipase C beta 3 [Source:RGD Symbol;Acc:61993] |
| Ensembl ID | ENSRNOG00000021150 |
| Bio databases IDs | |
| Aliases | phospholipase C beta 3 |
| Synonyms | LOC283126, mKIAA4098, phospholipase C beta 3, phospholipase C, beta 3, Phospholipase c β 3, phospholipase C, β 3, PLC beta3, PLC β 3, SMDCD |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Plcb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- Phosphatidylinositol-specific phospholipase C, Y domain
- Arginine and glutamate-rich 1
- calmodulin binding
- enzyme
- phospholipase C
- protein binding
- phosphoinositide-specific phospholipase C-like phosphodiesterase catalytic domain
- Pleckstrin homology-like domain
- PLC-beta C terminal
- Type III secretion protein YscO
- Protein of unknown function (DUF1154)
- EFh_PI-PLC
- Phosphatidylinositol-specific phospholipase C, X domain
- phosphoinositide phospholipase C
- Phospholipase C, catalytic domain (part: domain X)
- Phosphoinositide-specific phospholipase C, efhand-like
- Hemingway/CFA97
- Phospholipase C, catalytic domain (part: domain Y)
- PH domain
- tail domain
- PDZ binding motif
- Protein kinase C conserved region 2 (CalB)
- C2 domain
Pathways
Biological processes and signaling networks where the Plcb3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Adrenomedullin signaling pathway
- Antioxidant Action of Vitamin C
- Apelin Cardiomyocyte Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Cardiac Hypertrophy Signaling
- CCR3 Signaling in Eosinophils
- Cellular Effects of Sildenafil (Viagra)
- Chemokine Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- Dendritic Cell Maturation
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- fMLP Signaling in Neutrophils
- Gαq Signaling
- Huntington's Disease Signaling
- Leptin Signaling in Obesity
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- P2Y Purinergic Receptor Signaling Pathway
- Sphingosine-1-phosphate Signaling
- Synaptic Long Term Potentiation
- Thrombin Signaling
- UVA-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- ulceration
- non-insulin-dependent diabetes mellitus
- vitiligo
- diabetes mellitus
- experimentally induced airway hyperresponsiveness
- spondylometaphyseal dysplasia with corneal dystrophy
- myeloproliferative disorder
- liquid neoplasia
- myeloid neoplasia
role in cell
- expression in
- activation in
- phosphorylation in
- binding in
- production in
- formation
- formation in
- adhesion
- aggregation
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular space
- apical compartment
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- cytosol
- basolateral membrane
- sarcolemma
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Plcb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- phosphatidylinositol-mediated signaling
- regulation of systemic arterial blood pressure
- lipid catabolic process
- phosphatidylinositol metabolic process
- phospholipase C-activating G-protein coupled receptor signaling pathway
- release of sequestered calcium ion into cytosol
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol phospholipase C activity
- calmodulin binding
- protein binding
- calcium ion binding
- cadherin binding
- phospholipase C activity
- binding, bridging