Target List
Covers all exons in all known transcripts of targeted genes based on the Human GRCh38 genome build
Central Nervous System Cancers
Anaplastic Glial Tumors
CDKN2A (P16INK4A)CDKN2B (p15INK4b)PTENRB1TP53 (p53)
Astrocytomas
APCATRXBRAFCDKN2A (P16INK4A)CDKN2B (p15INK4b)CDKN2B-AS1CHEK2 (RAD53)FGFR1HIPK2HRASIDH1MSH2MYBNF1PALB2PTPN11RB1SDHATP53 (p53)TSC1
Atypical Teratoid Rhabdoid Tumors
SMARCA4SMARCB1
Craniopharyngiomas
BRAFCTNNB1
Ependymomas
CDKN2A (P16INK4A)ERBB2 (HER-2, NEU)MEN1NF2TP53 (p53)
Ganglioneuromas
ALKPHOX2B
Glioblastomas
ALKAPCBCORBRAFBRCA2CDK4CDKN2A (P16INK4A)CDKN2B (p15INK4b)CREBBP (CBP)EGFR (ERBB1)EPCAMERBB2 (HER-2, NEU)IDH1KIT (CD117)LZTR1MLH1MSH2MSH6MTORMYCNRASPIK3CA (p110-alpha)PMS2PTENRB1TP53 (p53)
Gliomas
ACVR1 (ALK2)ADGRB3ATRXBRAFBRCA2BRIP1CDKN2A (P16INK4A)CHD2CHEK2 (RAD53)CICEGFR (ERBB1)EP300FGFR1FLT1 (VEGFR1)H3-3AIDH1IRS2MDM4MYBMYCNNF1NSD2PDGFRAPIK3CA (p110-alpha)POT1PTENSTYK1TP53 (p53)
Hereditary Paraganglioma-Pheochromocytoma Syndrome
MAXSDHAF2SDHBSDHCSDHDTMEM127
Intercranial Ependymomas
CDKN2A (P16INK4A)CDKN2B (p15INK4b)
Lynch Syndrome
EPCAMMLH1MSH2MSH6PMS2
Medulloblastomas
ALPK2APCBRCA2CACNA1DCDH1 (E-Cadherin)CDK4CHD7CLTCL1CREBBP (CBP)CTCFCTNNB1DDX3XDDX60DEPDC5DICER1DNAH14DYNC1H1ERBB2 (HER-2, NEU)FAPFCRL2FGFR1GABRG1GPAMHDAC9IDH1IFIT3IRX2KAT6AKDM4CKDM6AKIF7KMT2BKMT2DLRRK1LRRK2MAST4MSH2MYCMYCNNCAPD3NLRP5NRASNRP1OTOFOTX2PARP2PCDHGB3PFKPPIK3CA (p110-alpha)PRKAG2PRLRPTCH1PTCH2PTENRAB11FIP1RB1SF3B1SMARCA4SMARCB1SUFUTP53 (p53)TPOTTNWDFY3WDFY4WRNZMYM3
Meningiomas
CDKN2A (P16INK4A)CDKN2B (p15INK4b)G6PDMN1NF2PDGFBPTENSMARCE1SUFU
Neuroblastomas
ALKBRCA1BRCA2DICER1EZH2HRASKIF1BNRASPHOX2BPTCH1PTPN11SMARCA4TP53 (p53)
Neurofibromas
EPCAMMLH1MSH2MSH6NF1PMS2
Neurofibromatosis
NF1NF2
Oligodendrogliomas
CDKN2A (P16INK4A)CDKN2B (p15INK4b)IDH1MSH2RB1
Tuberous Sclerosis Complex
TSC1TSC2
Other Central Nervous System Cancer Genes
AIPCDKN1B (P27KIP1)EPHB2PRKAR1AVHL
Colorectal Cancers
Adenocarcinomas
APCATMAXIN2BMPR1A (ALK3)BRAFBRCA1BRCA2CHEK2 (RAD53)EP300FLCNMLH1MLH3MSH2MSH3MSH6MUTYHNRASPALB2PMS1PMS2POLD1POLEPTENRNF43SMAD4 (MADH4)STK11 (LKB1)TGFBR2TP53 (p53)
Colorectal Cancer Susceptibility
CCND1GALNT12POLD1POLESMAD7
Familial Adenomatous Polyposis
APCMSH3MUTYHNTHL1POLD1POLE
Hereditary Mixed Polyposis Syndrome
BMPR1A (ALK3)GREM1
Hereditary Nonpolyposis
BRAFEPCAMMLH1MLH3MSH2MSH6PMS1PMS2TGFBR2
Hereditary Polyposis Syndrome
BMPR1A (ALK3)GREM1
Juvenile Polyposis Syndrome
BMPR1A (ALK3)SMAD4 (MADH4)
Lynch Syndrome
BRAFEPCAMMLH1MLH3MSH2MSH6PMS1PMS2TGFBR2
Metastatic Colorectal Cancers
ATMBRAFNRAS
Muir-Torre Syndrome
MLH1MSH2
Other Colorectal Cancer Genes
AURKABLMCDH1 (E-Cadherin)PKHD1PLA2G2ARB1RPS20SEMA4ATLR2XRCC2
Gastric Cancers
Gastrointestinal Stromal Tumors (GIST)
KIT (CD117)NF1PDGFRASDHBSDHCSDHDTMEM127
Lynch Syndrome
EPCAMMLH1MSH2MSH6PMS2
Multiple Endocrine Neoplasia
CDKN1B (P27KIP1)MEN1
Other Gastric Cancer Genes
APCATMBMPR1A (ALK3)CDH1 (E-Cadherin)CHEK2 (RAD53)CTNNA1KRASSMAD4 (MADH4)STK11 (LKB1)TP53 (p53)
Hematological Malignancies
Eosinophilia
CR2JAK1
Lymphoproliferative Disorders
PLAASH2D1AXIAP
Mastocytosis
DNMT3AIDH2KIT (CD117)NRASRUNX1 (AML1)
Multiple Myeloma
ATMCCND1IDH1IDH2KIT (CD117)LIG4NRASTP53 (p53)
Myelodysplastic Syndromes
CEBPADNMT3AGATA2GNB1IDH1IDH2KIT (CD117)MPLMSH6NF1NRASRUNX1 (AML1)SMAD9TERCTERTTP53 (p53)
Myelofibrosis
DNMT3AIDH1IDH2MPLNF1NRASTP53 (p53)
Myeloproliferative Neoplasms
DNMT3AIDH1IDH2MPLRUNX1 (AML1)SH2B3TP53 (p53)
Polycythemia Vera
DNMT3AIDH1NRASTP53 (p53)
Thrombocythemia
IDH2MPLSH2B3THPOTP53 (p53)
Other Hematological Malignancies Genes
BLMEPCAMHRASMLH1MSH2NBNPMS2
Hereditary Breast & Ovarian Cancers (HBOC)
Familial Breast-Ovarian Cancer Susceptibility
BRCA1BRCA2FGFR2MAP3K1 (MEKK1)RAD51CRAD51DTOX3
Breast Cancer Carcinomas
ATMBARD1BRCA1BRCA2BRIP1CHEK2 (RAD53)ERBB2 (HER-2, NEU)ESR1 (ERα)MLH1MSH2MSH6PALB2PIK3CA (p110-alpha)PMS2RAD51CRAD51D
Breast Cancer Ductal Carcinomas
CDH1 (E-Cadherin)FGFR2MRE11NBNSTK11 (LKB1)TP53 (p53)
Breast Cancer Susceptibility
BARD1BRCA2PALB2RECQLXRCC3
Metastatic Breast Cancers
BRCA1BRCA2ERBB2 (HER-2, NEU)ESR1 (ERα)NF1PALB2PIK3CA (p110-alpha)PTEN
Other Breast Cancer Genes
APCAXIN2SDHBSMARCA4TSHR
Ovarian Cancer Epithelial Carcinomas
ABRAXAS1ATMBARD1BRCA1BRCA2BRIP1CHEK2 (RAD53)ERBB2 (HER-2, NEU)MRE11NBNNF1PALB2PIK3CA (p110-alpha)PTENRAD51CRAD51DTP53 (p53)
Ovarian Cancer Mixed Adenosquamous Carcinomas
BLMCDH1 (E-Cadherin)DICER1FANCCFANCMFGFR2RAD50RAD51SMARCA4STK11 (LKB1)
Other Ovarian Cancer Genes
MLH1RECQLRINT1XRCC2
Uterine Serous Carcinomas
BLMCDH1 (E-Cadherin)DICER1FANCCFANCMFGFR2RAD50RAD51SMARCA4
Lynch Syndrome
EPCAMMLH1MSH2MSH6PMS2
Other Hereditary Breast & Ovarian Cancer Genes
HMMRMUTYHNQO2PGRPHBPOLD1PRKAR1A
Kidney Cancers
Hamartomas
CDC73DIS3L2
Lynch Syndrome
EPCAMMLH1MSH6PMS2
Nephroblastomas
CDKN1C (p57Kip2)DIS3L2TRIM28
Papillary Renal Cell Carcinomas
FHMET
Renal Cell Carcinomas
BAP1BRAFFGFR3FHFLCNHNF1AHNF1BMETMITFMSH2MTORNRASPIK3CA (p110-alpha)PTENSDHASDHBSDHCSDHDTMEM127TP53 (p53)VHL
Rhabdoid Tumors
SMARCA4SMARCB1
Tuberous Sclerosis Complex
TSC1TSC2
Wilms Tumors
BRAFBRCA2CDC73CDKN1C (p57Kip2)DICER1DIS3L2FZD6GPC3PAX6RESTVHLWT1
Other Kidney Cancer Genes
BUB1B
Myeloid Neoplasms
Acute Lymphoblastic Leukemia (ALL)
BRAFCDKN2A (P16INK4A)CDKN2B (p15INK4b)CREBBP (CBP)EP300ETV6EZH2FBXW7FLT3GATA3H2AC7H2BC6H2BC7H3C4H4C4IKZF1IKZF2IKZF3IL7RJAK1JAK2JAK3KRASMAPK1 (ERK2)NF1NOTCH1NRASPAG1PAX5PTENPTPN11RB1RUNX1 (AML1)SH2B3TP53 (p53)
Acute Megakaryoblastic Leukemia (AMKL)
ERGGATA1JAK2METMPLOLIG2RUNX1 (AML1)SMOTMPRSS2
Acute Myeloid Leukemia (AML)
BRCA2CEBPACHIC2DDX41DNMT3AETV6FLT3GATA1GATA2IDH1IDH2IKZF1IKZF2IKZF3JAK2KIT (CD117)KRASLPPMLLT10NRASPTPN11RB1RUNX1 (AML1)SH3GL1TERTTP53 (p53)WT1
Acute Promyelocytic Leukemia (APML; APL)
CEBPARUNX1 (AML1)
Atypical Chronic Myeloid Leukemia (aCML)
CBLCEBPAEZH2FLT3JAK2KRASNRASRUNX1 (AML1)SETBP1
B Cell Acute Lymphoblastic Leukemia (B-ALL)
IKZF1JAK1JAK2PAX5
Chronic Lymphocytic Leukemia (CLL)
BRAFGNB1NOTCH1NRASPTPN11TP53 (p53)
Chronic Myeloid Leukemia (CML)
BRAFCBLCREBBP (CBP)DNMT3AEZH2IDH1IDH2IKZF1JAK2KRASNRASRUNX1 (AML1)TP53 (p53)WT1
Chronic Myelomonocytic Leukemia (CMML)
CBLCEBPADNMT3AEZH2FLT3IDH1IDH2JAK2KIT (CD117)KRASMPLNF1NRASPHF6PTPN11RUNX1 (AML1)SETBP1TP53 (p53)
Early T-Cell Precursor Acute Lymphoblastic Leukemia
BCL11BBRAFCDKN2A (P16INK4A)CDKN2B (p15INK4b)CTCFDCLRE1CDNM2ECT2LEEDEP300ETV6EZH2FBXW7FLT3GATA2GATA3H1-5HNRNPA1HNRNPRIKZF1IL7RJAK1JAK3KRASLEF1LMO2MYBNF1NOTCH1NRASPHF6PTENPTPN11RB1RELNRUNX1 (AML1)SETD2SH2B3SUZ12TAL1WT1
Hairy Cell Leukemia
BRAFTP53 (p53)
Juvenile Myelomonocytic Leukemia
CBLKRASNF1NRASPTPN11
T Cell Acute Lymphoblastic Leukemia (T-ALL)
FBXW7NOTCH1
Other Leukemia Genes
APCATMCDH1 (E-Cadherin)DICER1DNAJC21ERBB3ERCC2 (XPD)ERCC4KCNQ1MSH2MSH6MUTYHNBNNSD1RECQL4RETSOS1STK11 (LKB1)TSC2
Acute Lymphoblastic Lymphomas
CDKN2A (P16INK4A)CDKN2B (p15INK4b)NOTCH1TP53 (p53)
B Cell Lymphomas
BRAFCHEK2 (RAD53)EZH2TP53 (p53)
Follicular Lymphomas
CREBBP (CBP)EP300EZH2
Non-Hodgkin Lymphomas
BRAFNRASPIK3CA (p110-alpha)TP53 (p53)
T Cell Lymphomas
ATMDNMT3AHAVCR2IDH1IDH2JAK1JAK3SETD2
Other Lymphoma Genes
B2MBRCA2CEBPAKIT (CD117)KLHDC8BMSH2MSH6MUTYHPRF1PTPN11RB1RECQL4RETSTK11 (LKB1)TSC2
Myelodysplastic Syndromes
CBLCEBPADDX41DNMT3AETV6EZH2FLT3GATA2GNB1IDH1IDH2JAK2JAK3KIT (CD117)KRASMPLNF1NRASPHF6PTPN11RUNX1 (AML1)SETBP1TERCTERTTP53 (p53)WT1
Myeloproliferative Neoplasms
CBLDNMT3AEZH2IDH1IDH2JAK2MPLRUNX1 (AML1)SH2B3TP53 (p53)
Essential Thrombocythemia
CBLIDH2JAK2MPLTP53 (p53)
Fanconi Anemia
FANCAFANCBFANCD2FANCEFANCFFANCGFANCIFANCMSLX4
Mastocytosis
CBLEZH2IDH2JAK2KIT (CD117)KRASNRASRUNX1 (AML1)
Multiple Myeloma
ATMBRAFBRCA2CHEK2 (RAD53)FANCLIDH1IDH2KIT (CD117)KRASMETNRASRETTP53 (p53)
Polycythemia Vera
DNMT3AEZH2IDH1JAK2NRASTP53 (p53)
Primary Myelofibrosis
CBLDNMT3AEZH2IDH1IDH2JAK2MPLNF1NRASSETBP1TP53 (p53)
Systemic Mastocytosis
CBLDNMT3AETV6EZH2IDH2JAK2KIT (CD117)KRASNRASRUNX1 (AML1)SETBP1
Pancreatic Cancers
Adenocarcinomas
ATMBRCA1BRCA2CDKN2A (P16INK4A)CFTREPCAMFANCCMLH1MSH2MSH6PALB2PALLDPMS2PRSS1SMAD4 (MADH4)SPINK1STK11 (LKB1)TP53 (p53)
Adenomas
TSC1TSC2
Familial Pancreatic Cancers
ATMBRCA2CDKN2A (P16INK4A)PALB2
Hereditary Pancreatitis
CFTRCTRCPRSS1PRSS2SPINK1
Lynch Syndrome
EPCAMMLH1MSH2MSH6PMS2
Multiple Endocrine Neoplasia
CDKN1B (P27KIP1)MEN1
Pancreatic Cancer Susceptibility
BRCA1BRCA2PALB2PALLDRABL3
Other Pancreatic Cancer Genes
APCBMPR1A (ALK3)CASRCDK4CPA1NF1VHL
Pediatric Cancers
Craniopharyngiomas
APCSMARCA4SUFUTSC1
Embryonal Rhabdomyosarcomas
CARD11CTNNB1FGFR4HRASKRASMDM2MDM4NF1NRASPIK3CA (p110-alpha)RARATP53 (p53)
Ependymomas
MEN1NF2
Ewing's Sarcoma
NF1RET
Germ Cell Tumors
BRAFCBLFANCMPTEN
Hepatoblastomas
CDK4MSH6TP53 (p53)
Hepatocellular Carcinomas
APCCREBBP (CBP)CTNNB1IDH1KRASMETNRASPIK3CA (p110-alpha)TERTTP53 (p53)
Lynch Syndrome
EPCAMMLH1PMS2
Nephroblastomas
BRCA2CDKN1C (p57Kip2)DIS3L2PAX6POU6F2RESTSMARCB1WT1
Neuroblastomas
ALKPHOX2BPTCH1
Osteosarcomas
ATRXCDKN2A (P16INK4A)CHEK2 (RAD53)RB1RECQL4TP53 (p53)TSC2
Retinoblastomas
APCCEBPAMAXRB1STK11 (LKB1)TSC2
Rhabdomyosarcomas
BRCA1DICER1FOXO1MSH2PAX3PAX7
Other Pediatric Cancer Genes
CDC73PRKAR1AVHL
Prostate Cancers
Adenocarcinomas
ARBRIP1CHEK2 (RAD53)NBNPTENRAD51CRAD51DTP53 (p53)
Advanced Prostate Cancers
ATMBRCA1BRCA2PALB2PTEN
Lynch Syndrome
EPCAMMLH1MSH2MSH6PMS2
Other Prostate Cancer Genes
CDH1 (E-Cadherin)EHBP1ELAC2HOXB13MSMBRNASEL
Skin Cancers
Cutaneous Melanomas
BAP1CDK4CDKN2A (P16INK4A)MC1RMITFPOT1XRCC3
Malignant Melanoma Susceptibility
CDK4CDKN2A (P16INK4A)MC1RMITFPOT1TERTXRCC3
Malignant Melanomas
CDK4CDKN2A (P16INK4A)MC1RMITFPOT1XRCC3
Melanomas
BRAFBRCA1BRCA2CDK4CDKN2A (P16INK4A)CDKN2B-AS1CREBBP (CBP)IDH1KIT (CD117)KRASMAP2K1MAP2K2 (MEK2)MC1RMITFNRASPIK3CA (p110-alpha)POT1PTENRAF1RB1TERTTP53 (p53)TYR
Uveal Melanomas
BAP1BRCA2CDKN2A (P16INK4A)CDKN2B (p15INK4b)
Xeroderma Pigmentosum
DDB2ERCC2 (XPD)ERCC3 (XPB)ERCC4ERCC5POLHXPAXPC
Other Skin Cancer Genes
ATRCYLDFHFLCNPRKAR1APTCH2