Nags Gene Summary [Rat]
Predicted to enable L-glutamate N-acetyltransferase activity. Predicted to be involved in L-arginine biosynthetic process and glutamate metabolic process. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in N-acetylglutamate synthase deficiency and amino acid metabolic disorder. Orthologous to human NAGS (N-acetylglutamate synthase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nags |
| Official Name | N-acetylglutamate synthase [Source:RGD Symbol;Acc:1565783] |
| Ensembl ID | ENSRNOG00000020879 |
| Bio databases IDs | |
| Aliases | N-acetylglutamate synthase |
| Synonyms | 1700120E20Rik, AGAS, AI415708, ARGA, N-acetylglutamate synthase, RGD1565783 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nags often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- amino-acid N-acetyltransferase
- enzyme
- DUF619-like
- AAK
- Amino acid kinase family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung squamous cell carcinoma
- diabetes mellitus
- glioblastoma cancer
- glioma formation
- hyperammonemia type III
- hereditary disorder
- glioblastoma
- organismal death
- squamous cell lung cancer
- gastric adenocarcinoma
regulates
- acetyl-coenzyme A
- L-glutamic acid
- PGAM5
role in cell
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nags gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutamate metabolic process
- arginine biosynthetic process
- urea cycle
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- acetyl-CoA:L-glutamate N-acetyltransferase activity