Krt8 Gene Summary [Rat]
Predicted to enable scaffold protein binding activity. Involved in response to hydrostatic pressure and sarcomere organization. Located in keratin filament; myofibril; and sarcolemma. Part of dystrophin-associated glycoprotein complex. Human ortholog(s) of this gene implicated in liver cirrhosis. Orthologous to human KRT8 (keratin 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Krt8 |
| Official Name | keratin 8 [Source:RGD Symbol;Acc:2984] |
| Ensembl ID | ENSRNOG00000009779 |
| Bio databases IDs | |
| Aliases | keratin 8 |
| Synonyms | CARD2, CK-8, Ck A, CYK8, CYKER, Ecp, EndoA, K2C8, K8, Ker8, keratin 8, Keratin complex 2, basic, gene 8, KO, Krt-2.8, Krt2-8, TROMA-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Krt8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Myosin-like coiled-coil protein
- binding protein
- alpha helix
- SWI5-dependent HO expression protein 3
- tail domain
- protein binding
- Intermediate filament protein
- head domain
Pathways
Biological processes and signaling networks where the Krt8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic steatosis
- neoplasia
- diabetes mellitus
- asthma
- diarrhea
- prostate cancer
- chronic sinusitis
- prostatic carcinoma
- epithelial cancer
- opioid dependence
role in cell
- number
- quantity
- activity
- expression in
- apoptosis
- proliferation
- formation
- cell cycle progression
- cell death
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- apicolateral membrane
- intermediate filament cytoskeleton
- cytoskeleton
- cell periphery
- apical compartment
- focal adhesions
- cell cortex
- Mitochondria
- intermediate filaments
- costameres
- intercellular junctions
- desmosomes
- cytosol
- nucleoplasm
- nucleoli
- nuclear scaffolds
- m-bands
- sarcolemma
- Z line
- keratin intermediate filaments
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Krt8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to hydrostatic pressure
- tumor necrosis factor-mediated signaling pathway
- cell differentiation involved in embryonic placenta development
- response to other organism
- sarcomere organization
- extrinsic apoptotic signaling pathway
- hepatocyte apoptotic process
Cellular Component
Where in the cell the gene product is active
- apicolateral plasma membrane
- costamere
- intermediate filament
- nucleoplasm
- Z disc
- nucleus
- extracellular vesicular exosome
- cell-cell junction
- keratin filament
- intermediate filament cytoskeleton
- cytoplasm
- sarcolemma
- dystrophin-associated glycoprotein complex
- cytosol
- nuclear matrix
Molecular Function
What the gene product does at the molecular level
- scaffold protein binding
- protein binding