SLCO1A2 Gene Summary [Human]
This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Details
| Type | Protein Coding |
| Official Symbol | SLCO1A2 |
| Official Name | solute carrier organic anion transporter family member 1A2 [Source:HGNC Symbol;Acc:HGNC:10956] |
| Ensembl ID | ENSG00000084453 |
| Bio databases IDs | |
| Aliases | solute carrier organic anion transporter family member 1A2 |
| Synonyms | OATP, OATP1A2, OATP-A, SLC21A3, SLCO1A3, solute carrier organic anion transporter family member 1A2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLCO1A2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- organic cation transporter
- Organic Anion Transporter Polypeptide (OATP) family
- sodium-independent organic anion transporter
- Major Facilitator Superfamily
- bile acid transporter
- KAZAL_FS
- organic anion transporter
- transporter
Pathways
Biological processes and signaling networks where the SLCO1A2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- Bamet-UD2
- Bamet-R2
- NR1I2
- rifampin
- chlorambucil-taurocholate
disease
- asthma
- myopathy
- intrahepatic cholestasis
- progressive supranuclear palsy
- sporadic amyotrophic lateral sclerosis
regulated by
- ketoconazole
- rifampin
- FOXA2
- hydrocortisone
- PDGF-BB
- indinavir
- lovastatin
- erythromycin
- LY294002
- nelfinavir
regulates
- methotrexate
- bilirubin
- Bamet-UD2
- diaminneplatinum(II)-chlorocholylglycinate
- bile salt
- deltorphin II
- bile salts and acids
- organic anion
- organic cation
- steroid
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
- basolateral membrane
- basal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLCO1A2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transport
- organic cation transport
- transmembrane transport
- xenobiotic metabolic process
- sodium-independent organic anion transport
- organic anion transport
- bile acid and bile salt transport
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- basolateral plasma membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- bile acid transmembrane transporter activity
- organic cation transmembrane transporter activity
- transmembrane transporter activity
- organic anion transmembrane transporter activity
- sodium-independent organic anion transmembrane transporter activity