Tas2r108 Gene Summary [Rat]
Predicted to enable bitter taste receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of bitter taste. Predicted to act upstream of or within respiratory gaseous exchange by respiratory system. Predicted to be located in ciliary membrane. Predicted to be active in membrane. Orthologous to human TAS2R4 (taste 2 receptor member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tas2r108 |
| Official Name | taste receptor, type 2, member 108 [Source:RGD Symbol;Acc:1561194] |
| Ensembl ID | ENSRNOG00000012195 |
| Bio databases IDs | |
| Aliases | taste receptor, type 2, member 108 |
| Synonyms | mGR08, mt2r8, T2R108, T2R16, T2R4, T2r8, Tas2r108, Tas2r8, taste 2 receptor member 4, taste receptor, type 2, member 108 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tas2r108 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- taste receptor
- Taste receptor protein (TAS2R)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Tas2r108 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- denatonium benzoate
disease
- gout
regulated by
- cisplatin
- denatonium benzoate
- NGEF
regulates
- Ca2+
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tas2r108 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- detection of chemical stimulus involved in sensory perception of bitter taste
- respiratory gaseous exchange
Cellular Component
Where in the cell the gene product is active
- membrane
- cilium membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- taste receptor activity
- bitter taste receptor activity