TAS2R4 Gene Summary [Human]
This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TAS2R4 |
| Official Name | taste 2 receptor member 4 [Source:HGNC Symbol;Acc:HGNC:14911] |
| Ensembl ID | ENSG00000127364 |
| Bio databases IDs | |
| Aliases | taste 2 receptor member 4 |
| Synonyms | mGR08, mt2r8, T2R108, T2R16, T2R4, T2r8, Tas2r108, Tas2r8, taste 2 receptor member 4, taste receptor, type 2, member 108 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TAS2R4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- taste receptor
- Taste receptor protein (TAS2R)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the TAS2R4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TAS2R4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- detection of chemical stimulus involved in sensory perception of bitter taste
- respiratory gaseous exchange
Cellular Component
Where in the cell the gene product is active
- membrane
- cilium membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- taste receptor activity
- bitter taste receptor activity