H2-T3 Gene Summary [Mouse]
Predicted to enable several functions, including beta-2-microglobulin binding activity; peptide antigen binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be located in several cellular components, including Golgi apparatus; cell surface; and endoplasmic reticulum. Predicted to be part of MHC class I protein complex and MHC class Ib protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in small intestine and thymus. [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | H2-T3 |
| Official Name | histocompatibility 2, T region locus 3 [Source:MGI Symbol;Acc:MGI:95959] |
| Ensembl ID | ENSMUSG00000054128 |
| Bio databases IDs | |
| Aliases | histocompatibility 2, T region locus 3 |
| Synonyms | H2-T18, H2-Tw3, histocompatibility 2, T region locus 3, LOC108348140, MumuTL, RT1 class Ib, locus T18, RT1-T18, TL, Tla |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse H2-T3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- MHC class I protein binding
- Class I Histocompatibility antigen, domains alpha 1 and 2
- natural killer cell lectin-like receptor binding
- TAP binding
- immunoglobulin domain
- T-cell receptor binding
- receptor binding
- chaperone binding
- transmembrane receptor
- peptide antigen binding
- beta-2-microglobulin binding
Pathways
Biological processes and signaling networks where the H2-T3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Allograft Rejection Signaling
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- Autoimmune Thyroid Disease Signaling
- Calcium-induced T Lymphocyte Apoptosis
- CDC42 Signaling
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Dendritic Cell Maturation
- Glucocorticoid Receptor Signaling
- Graft-versus-Host Disease Signaling
- iCOS-iCOSL Signaling in T Helper Cells
- Neuroinflammation Signaling Pathway
- Nur77 Signaling in T Lymphocytes
- OX40 Signaling Pathway
- PKCθ Signaling in T Lymphocytes
- Role of NFAT in Regulation of the Immune Response
- T Cell Receptor Signaling
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Th2 Pathway
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- phagosomes