DAP Gene Summary [Human]
This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Details
| Type | Protein Coding |
| Official Symbol | DAP |
| Official Name | death associated protein [Source:HGNC Symbol;Acc:HGNC:2672] |
| Ensembl ID | ENSG00000112977 |
| Bio databases IDs | |
| Aliases | death associated protein, death associated protein 1 |
| Synonyms | 4921531N22Rik, DAP1, death-associated protein, DEATH ASSOCIATED protein1, RAP7A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DAP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death-associated protein
- transcription regulator
- protein domain specific binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- mature B-cell neoplasia
- inflammatory bowel disease
- ulcerative colitis
- plasma cell neoplasm
- B cell cancer
- COVID-19
- pulmonary tuberculosis
- Crohn disease
role in cell
- apoptosis
- growth
- autophagy by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DAP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- negative regulation of transcription, DNA-dependent
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of autophagy
- autophagy
- cellular response to amino acid starvation
- apoptotic process
- apoptotic signaling pathway
- activation of cysteine-type endopeptidase activity involved in apoptotic process
Molecular Function
What the gene product does at the molecular level
- death domain binding