FCGR1B Gene Summary [Human]
Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified (Fcgamma RI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This gene likely encodes a non-functional protein that is not detectable at the cell surface and binds ligand with low affinity. [provided by RefSeq, Nov 2019]
Details
| Type | Retained Intron |
| Official Symbol | FCGR1B |
| Official Name | Fc fragment of IgG receptor Ib [Source:HGNC Symbol;Acc:HGNC:3614] |
| Ensembl ID | ENSG00000198019 |
| Bio databases IDs | |
| Aliases | Fc fragment of IgG receptor Ib, Fc gamma receptor Ib, pseudogene |
| Synonyms | CD34, CD64b, FCG1, Fc gamma receptor Ib, pseudogene, FcgammaRIa, FCGR1, FCGR1B, FcRI, Fc γ receptor Ib, pseudogene, IGFR1, IGFRB |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FCGR1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sepsis
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- diffuse cutaneous systemic sclerosis
- septic shock
regulated by
- IFNG
- resiquimod
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endocytic vesicle membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FCGR1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- antibody-dependent cellular cytotoxicity
- Fc-gamma receptor signaling pathway
- cell surface receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- clathrin-coated endocytic vesicle membrane
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- IgG receptor activity
- immunoglobulin receptor activity
- IgG binding