GULOP Gene Summary [Human]
This gene is nonfunctional in humans and other primates. In most mammalian species the corresponding gene encodes L-gulono-gamma-lactone oxidase which catalyzes the last step of ascorbic acid biosynthesis. The human gene is a remnant that lacks five of twelve exons found in functional rodent genes. The loss of enzyme activity results in hypoascorbemia or the inability to synthesize vitamin C. [provided by RefSeq, Nov 2010]
Details
| Type | Unitary Pseudogene |
| Official Symbol | GULOP |
| Official Name | gulonolactone (L-) oxidase, pseudogene [Source:HGNC Symbol;Acc:HGNC:4695] |
| Ensembl ID | ENSG00000234770 |
| Bio databases IDs | |
| Aliases | gulonolactone (L-) oxidase, pseudogene |
| Synonyms | GULO, gulonolactone (L-) oxidase, pseudogene, SCURVY |
| Species | Human, Homo sapiens |
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- schizophrenia
- scurvy
- nicotine dependence
- cannabis dependence
- Alzheimer disease
- lung carcinoma
- lung carcinoma process
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown