FIGNL2 Gene Summary [Human]
Predicted to enable microtubule-severing ATPase activity. Predicted to be involved in cytoplasmic microtubule organization. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | FIGNL2 |
| Official Name | fidgetin like 2 [Source:HGNC Symbol;Acc:HGNC:13287] |
| Ensembl ID | ENSG00000261308 |
| Bio databases IDs | |
| Aliases | fidgetin like 2 |
| Synonyms | AABR07058914.1, EG668225, fidgetin-like 2, RGD1566321 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FIGNL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase family associated with various cellular activities (AAA)
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FIGNL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- morphogenesis of a branching structure
- microtubule severing
- negative regulation of axon regeneration
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- cell leading edge
- cell cortex
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- microtubule-severing ATPase activity