Slfn1 Gene Summary [Mouse]
Predicted to enable RNA nuclease activity and ribosome binding activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle; negative regulation of T cell proliferation; and negative regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including gut; male reproductive gland or organ; nervous system; oviduct; and spleen. Orthologous to human SLFN12 (schlafen family member 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slfn1 |
| Official Name | schlafen 1 [Source:MGI Symbol;Acc:MGI:1313259] |
| Ensembl ID | ENSMUSG00000078763 |
| Bio databases IDs | |
| Aliases | schlafen 1 |
| Synonyms | LOC688074, RGD1309755, schlafen 1, schlafen family member 1 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slfn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Putative DNA-binding domain
- ribonuclease
- ribosome binding
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- dextran sodium sulfate-induced colitis
role in cell
- growth
- proliferation
- quantity
- G1 phase
- cell cycle progression
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol