Tymp Gene Summary [Rat]
Predicted to enable protein homodimerization activity and thymidine phosphorylase activity. Predicted to be involved in several processes, including nucleobase-containing small molecule metabolic process; regulation of myelination; and regulation of transmission of nerve impulse. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); cytochrome-c oxidase deficiency disease (multiple); mitochondrial DNA depletion syndrome 1; mitochondrial encephalomyopathy; and myopia. Orthologous to several human genes including TYMP (thymidine phosphorylase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tymp |
| Official Name | thymidine phosphorylase [Source:RGD Symbol;Acc:1305756] |
| Ensembl ID | ENSRNOG00000032394 |
| Bio databases IDs | |
| Aliases | thymidine phosphorylase |
| Synonyms | Ecgf1, thymidine phosphorylase, TP |
| Species | Rat, Rattus norvegicus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tymp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Pyrimidine nucleoside phosphorylase C-terminal domain
- Glycosyl transferase family, helical bundle domain
- trpD
- pyrimidine-nucleoside phosphorylase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- Glycosyl transferase family, a/b domain
- SCO1/SenC
- protein homodimerization
- thymidine phosphorylase
- AhpC/TSA family
- enzyme
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown