RT1-M5 Gene Summary [Rat]
Predicted to enable peptide antigen binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be active in external side of plasma membrane and extracellular space. [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | RT1-M5 |
| Official Name | RT1 class Ib, locus M5 [Source:RGD Symbol;Acc:1595816] |
| Ensembl ID | ENSRNOG00000033136 |
| Bio databases IDs | |
| Aliases | RT1 class Ib, locus M5 |
| Synonyms | CRW2, D130003B22, D130003B22Rik, histocompatibility 2, M region locus 5, Hla-f, RGD1560260, RT1 class Ib, locus M5, RT1-M5, RT1.M5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rt1-M5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TAP2 binding
- Immunoglobulin C1-set domain
- MHC class I protein binding
- TAP binding
- TAP1 binding
- immunoglobulin domain
- T-cell receptor binding
- protein binding
- receptor binding
- identical protein binding
- beta-2-microglobulin binding
- Class I Histocompatibility antigen, domains alpha 1 and 2
- natural killer cell lectin-like receptor binding
- CD8 receptor binding
- protein homodimerization
- chaperone binding
- peptide antigen binding
Pathways
Biological processes and signaling networks where the Rt1-M5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
regulated by
- RGFP966
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- Golgi membrane
- lysosome membrane
- endosomal membrane
- early endosomes