Kcns1 Gene Summary [Rat]

Predicted to enable potassium channel regulator activity. Predicted to be involved in action potential; potassium ion transmembrane transport; and regulation of potassium ion transmembrane transport. Predicted to be located in nucleoplasm; perinuclear region of cytoplasm; and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Orthologous to human KCNS1 (potassium voltage-gated channel modifier subfamily S member 1). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Kcns1
Official Name
potassium voltage-gated channel, modifier subfamily S, member 1 [Source:RGD Symbol;Acc:621524]
Ensembl ID
ENSRNOG00000013681
Bio databases IDs NCBI: 117023 Ensembl: ENSRNOG00000013681
Aliases potassium voltage-gated channel, modifier subfamily S, member 1
Synonyms hKv9.1, KV9.1, K+ voltage-gated channel, subfamily S, 1, potassium voltage-gated channel modifier subfamily S member 1, potassium voltage-gated channel, modifier subfamily S, member 1
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kcns1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • delayed rectifier potassium channel
  • Ion transport protein
  • Broad-Complex, Tramtrack and Bric a brac
  • BTB_POZ
  • potassium channel regulator
  • protein binding
  • ion channel

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • bipolar disorder
  • pervasive developmental disorder
  • neuropathic pain
  • diabetic nephropathy
regulated by
regulates
  • K+
role in cell
  • excitability
  • firing

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • intracellular membrane-bounded organelle
  • Cytoplasm
  • perinuclear region
  • cellular membrane
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Kcns1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • potassium ion transport
  • potassium ion transmembrane transport
  • protein homooligomerization
  • regulation of action potential

Cellular Component

Where in the cell the gene product is active
  • perinuclear region of cytoplasm
  • voltage-gated potassium channel complex
  • membrane
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • delayed rectifier potassium channel activity
  • potassium channel regulator activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.