Nudt1 Gene Summary [Rat]
Predicted to enable nucleoside triphosphate diphosphatase activity and snoRNA binding activity. Involved in male gonad development and response to cadmium ion. Located in acrosomal vesicle; extracellular space; and nuclear membrane. Biomarker of hypertension. Orthologous to human NUDT1 (nudix hydrolase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nudt1 |
| Official Name | nudix hydrolase 1 [Source:RGD Symbol;Acc:621080] |
| Ensembl ID | ENSRNOG00000001260 |
| Bio databases IDs | |
| Aliases | nudix hydrolase 1 |
| Synonyms | 8-OXO-DGTPASE, MTH1, nudix hydrolase 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nudt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dATP pyrophosphohydrolase
- sulfuric ester hydrolase
- NUDIX domain
- phosphorous-containing acid anhydride hydrolase
- 7,8-dihydro-8-oxoguanine-triphosphatase
- nucleoside-triphosphate diphosphatase
- phosphatase
- snoRNA binding
- protein binding
- ATP diphosphatase
- 8-oxo-dGTP diphosphatase
- NUDIX hydrolase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- neurodegeneration
- microgliosis
- weight loss
- bleeding
- glioblastoma
- glioblastoma cancer
- epithelial cancer
- epithelial neoplasia
role in cell
- expression in
- proliferation
- cell death
- apoptosis
- production in
- transmembrane potential
- peroxidation in
- function
- aggregation
- exposure in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- mitochondrial matrix
- nuclear envelope
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nudt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- DNA repair
- purine nucleoside catabolic process
- male gonad development
- DNA protection
- response to cadmium ion
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- nuclear membrane
- cytoplasm
- mitochondrial matrix
- acrosomal vesicle
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP diphosphatase activity
- snoRNA binding
- protein binding
- metal ion binding
- dATP pyrophosphohydrolase activity
- hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
- 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
- 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity