KCNS1 Gene Summary [Human]

Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
KCNS1
Official Name
potassium voltage-gated channel modifier subfamily S member 1 [Source:HGNC Symbol;Acc:HGNC:6300]
Ensembl ID
ENSG00000124134
Bio databases IDs NCBI: 3787 Ensembl: ENSG00000124134
Aliases potassium voltage-gated channel modifier subfamily S member 1
Synonyms hKv9.1, KV9.1, K+ voltage-gated channel, subfamily S, 1, potassium voltage-gated channel modifier subfamily S member 1, potassium voltage-gated channel, modifier subfamily S, member 1
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KCNS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • delayed rectifier potassium channel
  • Ion transport protein
  • Broad-Complex, Tramtrack and Bric a brac
  • BTB_POZ
  • potassium channel regulator
  • protein binding
  • ion channel

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • bipolar disorder
  • pervasive developmental disorder
  • neuropathic pain
  • diabetic nephropathy
regulated by
regulates
  • K+
role in cell
  • excitability
  • firing

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • intracellular membrane-bounded organelle
  • Cytoplasm
  • perinuclear region
  • cellular membrane
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human KCNS1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • potassium ion transport
  • potassium ion transmembrane transport
  • protein homooligomerization
  • regulation of action potential

Cellular Component

Where in the cell the gene product is active
  • perinuclear region of cytoplasm
  • voltage-gated potassium channel complex
  • membrane
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • delayed rectifier potassium channel activity
  • potassium channel regulator activity

Gene-Specific Assays for Results You Can Trust

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