NBR2 Gene Summary [Human]
This gene was identified by its close proximity on chromosome 17 to tumor suppressor gene BRCA1. Experimental evidence indicates that the two genes share a bi-directional promoter. Transcription for either gene is controlled individually by distinct transcriptional repressor factors. A short (112 amino acid) open reading frame is observed which includes a region derived from a LINE1 element. A strong Kozak signal is not observed for the putative ORF and the stop codon is more than 55 nucleotides upstream of the last splice site for the transcript, suggesting that the transcript is subject to nonsense-mediated decay. Therefore, this gene does not appear to encode a protein. Glucose starvation induces the expression of this gene and the long non-coding RNA transcribed by it functions with AMP-activated protein kinase in mediating the energy stress response. [provided by RefSeq, Aug 2016]
Details
| Type | Long Non-Coding RNA |
| Official Symbol | NBR2 |
| Official Name | neighbor of BRCA1 lncRNA 2 [Source:HGNC Symbol;Acc:HGNC:20691] |
| Ensembl ID | ENSG00000198496 |
| Bio databases IDs | |
| Aliases | neighbor of BRCA1 lncRNA 2, non-protein coding RNA 192 |
| Synonyms | NCRNA00192, neighbor of BRCA1 lncRNA 2 |
| Species | Human, Homo sapiens |
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
- colon cancer
- organismal death
- non-small cell lung cancer
regulated by
- phenformin
- curcumin
- Caco2 cells
- MBD2
- C-phycocyanin
role in cell
- expression in
- apoptosis
- cell viability
- proliferation
- quantity
- phosphorylation in
- migration
- colony formation by
- proliferation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown