CDH2 Gene Summary [Human]
This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | CDH2 |
| Official Name | cadherin 2 [Source:HGNC Symbol;Acc:HGNC:1759] |
| Ensembl ID | ENSG00000170558 |
| Bio databases IDs | |
| Aliases | cadherin 2, N-cadherin |
| Synonyms | ACOGS, ADHD8, ARVD14, cadherin 2, CD325, CDHN, CDw325, N-CAD, N-cadherin, Neural cadherin |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDH2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- dimerization domain
- alpha-catenin binding
- protein kinase binding
- beta-catenin binding
- protein phosphatase binding
- ectodomain
- calcium ion binding
- enzyme binding
- protein binding
- identical protein binding
- N-cadherin C-terminal cytoplasmic domain
- RNA binding
- N-cadherin binding domain
- Cadherin, Y-type LIR-motif
- binding protein
- cytoplasmic domain
- gamma-catenin binding
- Cadherin prodomain like
- transmembrane domain
- Cadherin repeat-like domain
- intracellular domain
- cytosolic tail domain
- extracellular cadherin structural domain
Pathways
Biological processes and signaling networks where the CDH2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- reactive astrogliosis
- focal nodular hyperplasia
- gastric cancer
- proliferative diabetic retinopathy
- hyperplasia
- familial arrhythmogenic right ventricular dysplasia type 14
- agenesis of corpus callosum, cardiac, ocular, and genital syndrome
- neoplasia
- agenesis of corpus callosum
- airway fibrosis
role in cell
- phosphorylation in
- cell death
- binding in
- expression in
- morphology
- activation in
- cell-cell adhesion
- migration
- arborization
- area
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- nuclear membrane fraction
- detergent-insoluble fractions
- membrane fraction
- insoluble fractions
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- apicolateral membrane
- glutaminergic synapse
- cell junction
- cortical actin cytoskeleton
- Cytoplasm
- cell surface
- cell borders
- cell periphery
- basal compartment
- perisynaptic region
- perinuclear region
- membrane surface
- cellular membrane
- Nucleus
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- intercellular junctions
- desmosomes
- cell-cell contacts
- endoplasmic reticulum lumen
- microsome
- apical membrane
- presynaptic membrane
- synaptic membrane
- basolateral membrane
- lateral plasma membrane
- cis face of the Golgi apparatus
- trans face of the Golgi apparatus
- dendritic spines
- dendritic spine head
- growth cone
- neurites
- synaptosomes
- synapse
- intercalated disks
- sarcolemma
- secretory vesicles
- endocytotic vesicle
- transverse tubules
- membrane rafts
- cellular protrusions
- microvilli
- postsynaptic spines
- cell-cell adherens junctions
- lamellipodia
- detergent-soluble fraction
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDH2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuroepithelial cell differentiation
- adherens junction organization
- multicellular organismal development
- heterophilic cell-cell adhesion
- blood vessel morphogenesis
- synaptic vesicle clustering
- brain morphogenesis
- cell adhesion
- homophilic cell adhesion
- neuronal stem cell maintenance
- striated muscle cell differentiation
- regulation of oligodendrocyte progenitor proliferation
- cell migration
- detection of muscle stretch
- calcium-dependent cell-cell adhesion
- cell-cell junction assembly
- neural crest cell development
- cell morphogenesis
- radial glial cell differentiation
- cerebral cortex development
- positive regulation of MAPK cascade
- positive regulation of synaptic vesicle clustering
- type B pancreatic cell development
- negative regulation of canonical Wnt receptor signaling pathway
- synapse assembly
- cell-cell adhesion mediated by cadherin
- homeostasis of number of cells
- neuroligin clustering
- glial cell differentiation
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- apicolateral plasma membrane
- presynaptic active zone membrane
- neuron projection
- plasma membrane
- cell surface
- endoplasmic reticulum lumen
- adherens junction
- cell-cell junction
- focal adhesion
- apical part of cell
- cytoplasm
- sarcolemma
- fascia adherens
- cell junction
- intercalated disc
- desmosome
- catenin complex
- basolateral plasma membrane
- apical plasma membrane
- cortical actin cytoskeleton
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- alpha-catenin binding
- gamma-catenin binding
- protein kinase binding
- identical protein binding
- protein phosphatase binding
- protein binding
- RNA binding
- calcium ion binding
- cadherin binding
- beta-catenin binding